Can Progesterone Cause Birth Defects? Concerns for Future Mothers - Obstetrics and Gynecology

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I am currently experiencing abnormal bleeding and went to the hospital for a check-up.
The doctor prescribed me progesterone for 10 days, but I am quite anxious because I want to prepare for motherhood.
Can I conceive while taking progesterone? Will synthetic progesterone cause fetal abnormalities? Do I need to take progesterone every month? Are there other ways to naturally produce progesterone, or are there dietary supplements? Are there any books available for reference? Thank you, doctor, for taking the time to provide me with a detailed answer amidst your busy schedule.

Ji huà huái yùn de fù nǚ, 20~29 year old female. Ask Date: 2005/03/13

Dr. Li Guanghan reply Obstetrics and Gynecology


Hello: Long-term use of synthetic progesterone without knowledge of pregnancy may cause masculinization in female infants.
If your menstrual period is overdue, please visit an obstetrics and gynecology clinic immediately for a pregnancy test.
If you are pregnant, stop the medication right away, but do not worry excessively.
The ovaries can only produce progesterone normally after healthy ovulation, which depends on a regular routine, a balanced diet, appropriate exercise, a positive mood, and stress reduction.
Hsinchu City Hospital, Department of Obstetrics and Gynecology.

Reply Date: 2005/03/13

More Info


Progesterone, particularly in its micronized form (like Utrogestan), is often prescribed to women experiencing abnormal bleeding or those who are at risk of miscarriage due to low progesterone levels. Your concerns about the safety of progesterone during pregnancy and its potential effects on fetal development are valid, especially as you prepare for motherhood.

Firstly, it’s important to understand that progesterone plays a crucial role in maintaining pregnancy. It helps to prepare the uterine lining for implantation of the embryo and supports the early stages of pregnancy. In cases where a woman has low progesterone levels, supplementation can be beneficial and is often necessary to reduce the risk of miscarriage.
Regarding your specific concerns about birth defects, current medical literature suggests that progesterone, when used appropriately under medical supervision, does not increase the risk of congenital malformations. The available data indicates that progesterone is generally considered safe during pregnancy. However, it is essential to follow your healthcare provider's instructions closely and to have regular check-ups to monitor your health and the health of your developing baby.

As for your question about the possibility of conceiving while taking progesterone, it is indeed possible to become pregnant while on progesterone supplementation. In fact, if you are experiencing abnormal bleeding due to low progesterone levels, the supplementation may help stabilize your cycle and improve your chances of conception. However, if you are actively trying to conceive, it is crucial to communicate this with your healthcare provider, as they can provide tailored advice based on your specific situation.

You also asked whether progesterone needs to be taken every month. This typically depends on the underlying reason for its use. If you are using it to support a pregnancy or to regulate your menstrual cycle due to hormonal imbalances, your doctor will guide you on the appropriate duration and dosage. Some women may need to take it continuously, while others may only need it during specific phases of their cycle.

In terms of natural ways to support progesterone production, maintaining a healthy lifestyle can be beneficial. This includes a balanced diet rich in healthy fats, such as avocados, nuts, and seeds, which can support hormone production. Regular exercise, stress management techniques, and adequate sleep are also important for hormonal balance. While there are no specific foods that directly increase progesterone levels, a diet that supports overall hormonal health can be helpful.

If you are looking for resources or books on this topic, consider exploring literature on women's health, hormonal balance, and fertility. Books that focus on holistic approaches to reproductive health may provide valuable insights and practical advice.

In summary, while your concerns about progesterone are understandable, it is important to remember that when prescribed by a healthcare professional, it is generally safe and can be beneficial for both your health and the health of your future baby. Always consult with your healthcare provider for personalized advice and to address any ongoing concerns you may have. They can provide the most accurate information based on your health history and current situation.

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