Glycogen Storage Disease Type III: Can Cord Blood Help?

Glycogen storage disease type III

My daughter is a patient with Glycogen Storage Disease Type III, and I am currently pregnant with my second child.
I am wondering if the umbilical cord blood from the newborn could be beneficial for my daughter in the future.
She is currently three years and three months old and her height is only 90 cm; is this considered too short?

vency, 30~39 year old female. Ask Date: 2005/03/22

Dr. Lin Xiujuan reply Rare Disease

Currently, umbilical cord blood cannot treat glycogen storage disease.
The storage period for cord blood in Taiwan is approximately 20 to 50 years, unless a cord blood transplantation method for this disease is developed within that timeframe.
Height is related to the disease condition and dietary control.
Patients can return to the genetic counseling clinic for consultation and follow-up.

Reply Date: 2005/03/22

More Info

Glycogen Storage Disease Type III (GSD III), also known as Cori disease, is a metabolic disorder that affects the body's ability to break down glycogen, leading to an accumulation of abnormal glycogen in various tissues, particularly the liver and muscles. This condition can result in a range of symptoms, including hypoglycemia, muscle weakness, and growth delays.
Regarding your question about the potential benefits of cord blood for your daughter, it is important to clarify that, as of now, there is no established treatment for GSD III using cord blood. Cord blood is rich in hematopoietic stem cells, which can be used for certain blood disorders and some types of cancers, but it has not been proven effective for metabolic disorders like GSD III. The storage of cord blood typically lasts between 20 to 50 years, and unless significant advancements in treatment methods for GSD III are made within that timeframe, it is unlikely that the cord blood would provide any therapeutic benefit for your daughter.

As for your daughter's height, being 90 cm at three years and three months may be considered below the average height for her age, depending on various factors including genetics and overall health. Growth patterns can vary significantly among children, and it is essential to monitor her growth trajectory over time. Factors such as nutrition, hormonal levels, and the management of her condition can all influence her growth. It would be beneficial to consult with a pediatrician or a specialist in metabolic disorders to assess her growth and development comprehensively. They can provide guidance on dietary management and any necessary interventions to support her growth.

In managing GSD III, dietary control is crucial. A diet low in carbohydrates and high in protein may help manage symptoms and prevent hypoglycemia. Regular monitoring of blood glucose levels and maintaining a balanced diet tailored to her specific needs can also contribute positively to her overall health and growth.

Additionally, it is advisable to engage with a genetic counselor or a metabolic specialist who can provide more personalized insights into your daughter's condition and the implications for your new baby. They can also help you understand the potential risks of GSD III being passed on to your second child and discuss any prenatal testing options available.

In summary, while cord blood does not currently offer a treatment option for GSD III, focusing on proper dietary management and regular medical follow-ups can significantly impact your daughter's health and growth. Always consult with healthcare professionals who specialize in metabolic disorders for the most accurate and tailored advice.

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