Gastrointestinal stromal tumor (GIST)
DEAR DOCTOR,
My father is 63 years old and living in Hong Kong.
Last year, he was diagnosed with a gastrointestinal stromal tumor (GIST) in the small intestine, which caused severe bleeding, necessitating an urgent resection of the ileum.
After the surgery, a PET/CT scan revealed metastasis to the liver.
He then underwent a secondary surgery to resect the liver lesions.
Unfortunately, during a routine CT check-up three months later, a few small lesions were still present in the liver, and subsequent scans showed that these lesions (possibly GIST) had increased in size.
Upon the advice of his oncologist, my father began treatment with Gleevec (imatinib) as chemotherapy to try to control tumor growth.
Given my father's age, he wishes to stay with us in Taiwan (I am the only son in the family).
This month, my father will have another CT check-up in Hong Kong to monitor the size of the tumors.
If they become smaller or stable, it would indicate that Gleevec is effective.
If my father decides to stay in Taiwan, will he be able to receive continuous treatment and follow-up check-ups at your hospital? (Due to the Gleevec treatment, my father will need monthly blood tests and CT scans every three months to monitor tumor size.) Additionally, considering the cost of Gleevec, could you please inform me about the monthly treatment fees in Taiwan? Is this covered by the National Health Insurance Bureau?
Thank you for your attention.
FENGHUANG, 30~39 year old female. Ask Date: 2005/04/06
Dr. Fan Sheng reply Oncology
Dear Phonix: If your father is a citizen of the Republic of China and has paid his general health insurance fees regularly, he is certainly covered under the health insurance program.
Our General Health Bureau will approve GLEEVEC for metastatic GIST after physicians submit a formal application along with your father’s pathology reports, surgical findings, and current imaging studies such as a CT scan.
One capsule of GLEEVEC costs 626 New Taiwan Dollars.
The average dosage is 4 to 6 capsules per day.
It is a very expensive medical treatment if you plan to pay out of pocket.
Good luck, and thank you for your inquiry.
Reply Date: 2005/04/06
More Info
Managing Gastrointestinal Stromal Tumors (GISTs) can be quite complex, especially when dealing with metastatic disease. Your father's situation, having undergone surgery for a GIST and now facing metastasis to the liver, is indeed challenging. GISTs are a type of tumor that arises from the interstitial cells of Cajal in the gastrointestinal tract and can vary significantly in behavior, ranging from benign to malignant.
In terms of treatment options, the standard approach for GISTs, particularly those that are unresectable or metastatic, typically involves targeted therapy with imatinib (Gleevec). This medication has been shown to be effective in controlling the growth of GISTs by inhibiting the activity of the mutated c-KIT protein that drives the tumor's growth. The response to Gleevec can be monitored through regular imaging studies, such as CT scans, and blood tests to assess liver function and other parameters.
Regarding your father's desire to continue treatment in Taiwan, it is indeed possible for him to receive ongoing care there. Many hospitals in Taiwan are equipped to manage GISTs and can provide the necessary follow-up care, including monthly blood tests and quarterly CT scans to monitor the tumor's response to treatment. It would be advisable to consult with an oncologist at a reputable medical center in Taiwan to establish a treatment plan tailored to your father's needs.
As for the costs associated with Gleevec, it is important to note that the price can vary significantly depending on the healthcare facility and whether the medication is covered by national health insurance. In Taiwan, Gleevec is included in the National Health Insurance (NHI) program, which can help alleviate some of the financial burden. However, the exact out-of-pocket expenses may depend on your father's specific insurance plan and any additional services required during his treatment.
In general, the monthly cost of Gleevec can be substantial, often ranging from several hundred to over a thousand US dollars, depending on the dosage and the healthcare provider. It is crucial to discuss these financial aspects with the healthcare team in Taiwan to understand what costs will be covered and what might need to be paid out of pocket.
In summary, your father can receive continuous treatment in Taiwan, and it is essential to establish care with a local oncologist who specializes in GISTs. They will be able to provide the necessary follow-up care, manage the treatment regimen, and help navigate the financial aspects of care, including the costs associated with Gleevec and its coverage under the national health insurance system. It is also advisable to keep an open line of communication with the healthcare providers in Hong Kong to ensure a smooth transition of care.
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