Can Ankylosing Spondylitis Cause Diarrhea and Other Concerns?

Does ankylosing spondylitis cause diarrhea?

1.
Can ankylosing spondylitis cause diarrhea?
2.
Which specialty should be consulted for ankylosing spondylitis?
3.
Can the medications for ankylosing spondylitis harm the kidneys?
4.
What is the probability of passing it on to children? What is the incidence rate? Thank you!

anmakati, 30~39 year old female. Ask Date: 2005/06/01

Dr. Lin Xiaoyi reply Orthopedics

1.
The onset or exacerbation of ankylosing spondylitis may be related to gastrointestinal infections and diarrhea; some patients with ankylosing spondylitis may have inflammatory bowel conditions that can also cause diarrhea.
2.
Please consult a rheumatologist for evaluation and examination.
3.
If medications are taken as directed by the physician, they are unlikely to harm the kidneys, unless there are pre-existing kidney function issues.
However, regular kidney function monitoring is still necessary.
4.
The hereditary risk of ankylosing spondylitis passing to offspring is about 10%.
If a child's blood test for HLA-B27 is positive, there is approximately a 20% chance of developing the condition, with a higher incidence in boys.
However, the risk of onset can be reduced by avoiding infections or injuries, along with early diagnosis and treatment, so there is no need for excessive concern.

Reply Date: 2005/06/01

More Info

Ankylosing Spondylitis (AS) is a type of inflammatory arthritis that primarily affects the spine and the sacroiliac joints in the pelvis. It can lead to chronic pain and stiffness in the back and can also have systemic effects on other parts of the body. Let's address your questions one by one.

1. Can Ankylosing Spondylitis Cause Diarrhea?
Yes, Ankylosing Spondylitis can be associated with gastrointestinal symptoms, including diarrhea. This is particularly true if the patient has associated inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis, which can occur in conjunction with AS. The inflammation that characterizes AS can affect the gut, leading to symptoms like diarrhea, abdominal pain, and bloating. If you are experiencing persistent diarrhea, it is essential to consult a healthcare provider to rule out other potential causes and to manage your symptoms effectively.

2. Which Specialist Should You See for Ankylosing Spondylitis?
The primary specialist for Ankylosing Spondylitis is a rheumatologist. Rheumatologists specialize in autoimmune and inflammatory diseases, including various forms of arthritis. They can provide a comprehensive evaluation, diagnosis, and treatment plan tailored to your specific needs. If gastrointestinal symptoms are significant, you may also need to see a gastroenterologist, especially if there is a suspicion of IBD.

3. Can Medications for Ankylosing Spondylitis Harm the Kidneys?
Some medications used to treat Ankylosing Spondylitis, particularly nonsteroidal anti-inflammatory drugs (NSAIDs), can have renal side effects, especially with long-term use or in patients with pre-existing kidney conditions. It is crucial to monitor kidney function regularly if you are on these medications. Biologic therapies, which are often used for AS, generally have a better safety profile regarding kidney function, but they can still have other side effects. Always discuss your concerns with your healthcare provider, who can help you weigh the benefits and risks of your treatment options.

4. What is the Risk of Inheriting Ankylosing Spondylitis?
Ankylosing Spondylitis has a genetic component, and the presence of the HLA-B27 antigen is a significant risk factor. If a parent has AS, the likelihood of their children developing the condition is higher than in the general population. Studies suggest that the risk of developing AS in first-degree relatives (parents, siblings) of affected individuals is approximately 5-10%. However, not everyone who carries the HLA-B27 antigen will develop AS, and environmental factors also play a role in the disease's onset. The overall incidence of AS in the general population is estimated to be around 0.1% to 1%, depending on the demographic and geographic factors.

In summary, Ankylosing Spondylitis can indeed lead to gastrointestinal symptoms like diarrhea, and it is best managed by a rheumatologist. While some medications can affect kidney function, careful monitoring can mitigate risks. The hereditary aspect of AS suggests a higher risk for children of affected individuals, but not all will develop the condition. If you have further concerns or symptoms, it is advisable to seek medical attention for a comprehensive evaluation and management plan.

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