Blood Test Results: Identifying Types of Anemia - Cardiology

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Complete Blood Count (CBC)


Hello Dr.
Tang, I previously consulted you about some issues related to anemia.
I have also undergone electrophoresis testing, and the results are as follows: [1] WBC 7.34 (Eosin 1.2) [2] RBC 6.78 (Baso 1.3) [3] Hb 12.3 [4] Ht 40.6 [5] MCV 59.9 [6] MCH 18.1 [7] MCHC 30.3 [8] PL 128 [9] RDW-CV 22.8 [10] N.seg 73.6 [11] Lym 21.1 [12] Mono 3.8 [13] Ferritin 319.98 [14] HbA 97.59 [15] HbA2 2.41.
Based on these results, can you determine what type of anemia I might have? I appreciate your insights.
Best wishes.

SuNNy, 20~29 year old female. Ask Date: 2005/06/13

Dr. Tang Jieru reply Cardiology


Hello SuNNy: You have microcytic anemia.
Microcytic anemia is generally classified into two types: iron deficiency anemia or thalassemia.

1.
Your serum ferritin level is 319.98, which is within the normal range (>50), indicating that you do not have iron deficiency anemia; it is likely thalassemia.

2.
Thalassemia commonly presents as either alpha or beta types.
The beta type can be diagnosed through serum electrophoresis, where the result for HbA2 would be >4%.
Your test result is 2.41% (normal), so it is not beta thalassemia.

3.
Based on the above results, it can be indirectly inferred that you have alpha thalassemia.
There is no need for concern; you will not experience symptoms, and you should not take iron supplements (your iron levels are already sufficient, and additional intake could lead to excess).
Avoid taking any blood-boosting medications based on hearsay, as they are not meaningful.

Just be aware that when you get married, your partner should also be tested.
If both partners have thalassemia, there is a 25% chance that the child could have severe thalassemia.
Early in pregnancy, fetal testing should be conducted, and if it is unfortunately severe, termination may be advised.
However, there is no need to worry too much; even if both partners have thalassemia, there is still a 75% chance of having a normally developing child.
Thank you for your inquiry.

Reply Date: 2005/06/13

More Info


Based on the blood test results you provided, we can analyze the data to identify the type of anemia you may have. Let's break down the key components of your results:
1. Hemoglobin (Hb): Your level is 12.3 g/dL, which is on the lower side of the normal range for adult females (typically 12.0 to 15.5 g/dL) and slightly below for males (13.5 to 17.5 g/dL). This indicates that you may have anemia.

2. Mean Corpuscular Volume (MCV): Your MCV is 59.9 fL, which is significantly lower than the normal range (80-100 fL). A low MCV indicates microcytic anemia, which is often associated with iron deficiency or thalassemia.

3. Mean Corpuscular Hemoglobin (MCH): Your MCH is 18.1 pg, which is also below the normal range (27-32 pg). This further supports the diagnosis of microcytic anemia.

4. Mean Corpuscular Hemoglobin Concentration (MCHC): Your MCHC is 30.3 g/dL, which is within the normal range (32-36 g/dL). This suggests that while the red blood cells are smaller than normal, the concentration of hemoglobin within those cells is adequate.

5. Red Cell Distribution Width (RDW): Your RDW is 22.8%, which is elevated (normal range is typically 11.5-14.5%). An increased RDW indicates a variation in red blood cell size, which is often seen in conditions like iron deficiency anemia or mixed anemia.

6. Ferritin: Your ferritin level is 319.98 ng/mL, which is elevated. Ferritin is a marker of stored iron in the body. High ferritin levels can sometimes indicate inflammation or other conditions, but in the context of anemia, it may suggest that there is sufficient iron stored, which could point towards anemia of chronic disease rather than iron deficiency anemia.

Given these results, the most likely types of anemia to consider are:
- Iron Deficiency Anemia: This is characterized by low MCV and MCH, and typically low ferritin levels. However, your ferritin is elevated, which complicates this diagnosis.


- Anemia of Chronic Disease: This type of anemia is often associated with chronic infections, inflammatory diseases, or malignancies. It can present with normal or high ferritin levels, low MCV, and low iron levels.

- Thalassemia: This is a genetic disorder that can cause microcytic anemia. The elevated RDW and low MCV are consistent with this condition, but further testing (like hemoglobin electrophoresis) would be needed to confirm.

In conclusion, your blood test results suggest that you may have microcytic anemia, but the elevated ferritin level indicates that it might not be due to iron deficiency. It would be advisable to consult with your healthcare provider for further evaluation, which may include additional tests such as a reticulocyte count, iron studies (serum iron, total iron-binding capacity), and possibly a hemoglobin electrophoresis to clarify the type of anemia you have. Additionally, understanding your clinical history and any symptoms you may have will be crucial in determining the underlying cause of your anemia.

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