the Difference Between Spondyloarthritis and Seronegative Spondyloarthritis - Orthopedics

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Spondyloarthritis (SpA) is a term that encompasses a group of inflammatory rheumatic diseases that primarily affect the spine and the sacroiliac joints. One of the most well-known forms of spondyloarthritis is ankylosing spondylitis (AS), which is often associated with the HLA-B27 antigen. However, not all patients with spondyloarthritis test positive for this antigen, leading to the classification of "seronegative spondyloarthritis."
To clarify the terms:
1. Spondyloarthritis: This is a broader category that includes various types of inflammatory arthritis that affect the spine and may also involve peripheral joints. It encompasses conditions such as ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic arthritis (associated with inflammatory bowel disease).

2. Seronegative Spondyloarthritis: This term specifically refers to spondyloarthritis cases where the patient tests negative for the HLA-B27 antigen. This does not mean that the condition is less severe or different in nature; it simply indicates that the specific genetic marker is absent. Patients with seronegative spondyloarthritis can still experience significant symptoms and complications.

In your case, since your HLA-B27 test was negative, your doctor has classified your condition as "spondyloarthritis" rather than "ankylosing spondylitis." This means you may have a form of spondyloarthritis that does not involve the HLA-B27 antigen, which is common in many patients.
It’s important to note that while HLA-B27 is a significant marker, its absence does not rule out the presence of spondyloarthritis. There are many patients with spondyloarthritis who are HLA-B27 negative, and they may have similar symptoms and disease progression as those who are positive.
The distinction between "spondyloarthritis" and "seronegative spondyloarthritis" is primarily based on the presence or absence of the HLA-B27 antigen. Therefore, "脊椎關節病變" (spondyloarthritis) can indeed refer to "血清陰性脊椎關節病變" (seronegative spondyloarthritis) if the context indicates that the patient is HLA-B27 negative.
In terms of management and treatment, both conditions may be treated similarly, focusing on reducing inflammation, managing pain, and maintaining mobility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used, and in more severe cases, disease-modifying antirheumatic drugs (DMARDs) or biologics may be considered.

If you have further questions about your diagnosis or treatment options, it is advisable to have a detailed discussion with your rheumatologist. They can provide personalized insights based on your specific symptoms and medical history, ensuring that you receive the most appropriate care for your condition.