Pregnancy Concerns: Impact of Medications and X-Ray on Early Fetus - Obstetrics and Gynecology

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Hello, my last menstrual cycle was from June 5 to June 10 (which was about two days shorter than usual).
On June 28, I suddenly experienced abdominal pain, vomiting, diarrhea, and overall weakness with cold sweats.
In the evening, I went to the obstetrics and gynecology department for a pregnancy test (worried about potential medication issues if pregnant), and the result was negative.
The abdominal pain continued until July 1, so I visited a gastroenterology clinic.
The doctor mentioned abdominal fluid accumulation.
I had an X-ray and was hospitalized for two days.
On July 9, I had a follow-up appointment.
During July, I took four types of medication as follows: Antashin 400 mg/tab (Magaldrate), Kascoal 50 mg/tab (Dimethylpolysiloxane), Delibs F.C.
50 mg/tab (Pinaverium), and Buwecon Tid 0.125 mg/tab (Hyoscyamine), taking one of each after meals for a total of six days.
On July 14, I confirmed my pregnancy.
I would like to know if the medications and X-ray exposure could have any adverse effects on the fetus (I suspect that the fertilized egg was about 10 days old at the time of the X-ray).

You Ma, 30~39 year old female. Ask Date: 2005/07/14

Dr. Huang Jianxun reply Obstetrics and Gynecology


In principle, it is more appropriate for a prescribing physician to respond.

Reply Date: 2005/07/14

More Info


When it comes to early pregnancy, particularly in the first trimester, there are several concerns regarding the impact of medications and X-ray exposure on the developing fetus. Your situation involves a series of medical interventions, including X-ray imaging and the use of specific medications, which understandably raises concerns about potential risks to your pregnancy.

Firstly, regarding X-ray exposure, it is important to note that the first trimester is a critical period for fetal development. During the first few weeks after conception, the embryo is particularly sensitive to harmful agents, including radiation. The general consensus in the medical community is that low levels of radiation exposure, such as that from a single X-ray, are unlikely to cause significant harm to the fetus. However, the risk increases with higher doses of radiation. For instance, doses above 5-10 rads (or rem) are associated with an increased risk of congenital anomalies. Since you mentioned that the X-ray was performed when the fertilized egg was approximately 10 days old, it is essential to consider the cumulative radiation dose and whether it exceeded the threshold that could pose a risk.

In your case, if the X-ray exposure was within the range of typical diagnostic imaging (usually much lower than the threshold for concern), the risk of significant adverse effects on the fetus is likely minimal. However, it is always best to discuss specific details with your healthcare provider, who can assess the exact circumstances of your X-ray exposure.

Now, regarding the medications you took during this time, it is crucial to evaluate each one for potential teratogenic effects (the ability to cause birth defects). The medications you listed include:
1. Antashin (Magaldrate): This is an antacid used to relieve symptoms of excess stomach acid. It is generally considered safe during pregnancy, as it does not have known teratogenic effects.

2. Kascoal (Dimethylpolysiloxane): This medication is an anti-foaming agent used to relieve bloating and discomfort. It is also considered safe for use during pregnancy.

3. Delibs F.C. (Pinaverium): This is an antispasmodic medication. While there is limited data on its safety during pregnancy, it is not commonly associated with teratogenic effects.

4. Buwecon Tid (Hyoscyamine): This medication is used to treat various gastrointestinal disorders. Its safety during pregnancy is not well established, but it is generally used with caution.

Overall, while there is limited data on the specific medications you took, the available evidence suggests that the risk of teratogenic effects from these medications is low. However, it is essential to consult with your obstetrician or a maternal-fetal medicine specialist to discuss your specific situation and any potential risks.

In summary, while both X-ray exposure and medication use during early pregnancy can raise concerns, the actual risk of significant harm to the fetus depends on various factors, including the dosage and timing of exposure. It is crucial to have open communication with your healthcare provider, who can provide personalized advice based on your medical history and the specifics of your situation. Regular prenatal care and monitoring will also help ensure the health and well-being of both you and your baby throughout the pregnancy.

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