Weight Gain After Hormonal Medication: Is It Related?

Hormonal medication

Hello: Due to the absence of menstruation and not being pregnant, the doctor prescribed hormone medication for me, which I have taken for two days.
I have gained 2 kg, while my caloric intake and food quantity have remained the same.
Could this be related to the medication? Thank you!

Xiao Qing Tian, 20~29 year old female. Ask Date: 2005/07/17

Dr. Zhong Wenzhen reply Obstetrics and Gynecology

Hormonal medications generally contain progesterone, which has an antidiuretic effect, resulting in water retention of approximately 0.5 to 3 kg in the body.
This can lead to symptoms such as breast fullness, a feeling of heaviness in the lower abdomen due to uterine distension, and the disappearance of facial wrinkles, giving a radiant appearance.
To determine whether the weight gain is due to water retention from the medication or increased fat accumulation from diet, one can simply stop the medication for three days and weigh themselves.
The water retention effect of progesterone will dissipate within three days after discontinuation, allowing the individual to return to their original weight.

Reply Date: 2005/07/17

More Info

Weight gain after starting hormonal medication is a common concern for many individuals, and your experience of gaining 2 kg within just two days of starting hormonal treatment is certainly noteworthy. Hormonal medications can indeed influence body weight, and there are several mechanisms through which this can occur.

Firstly, hormonal medications, particularly those that contain estrogen or progestin, can lead to fluid retention. This is often a temporary effect and may not reflect an actual increase in body fat. Fluid retention can cause noticeable weight gain on the scale, but it may not be indicative of a change in your overall body composition. This is particularly common when starting hormonal treatments, as your body may need time to adjust to the new hormone levels.

Secondly, hormonal changes can affect your metabolism. Hormones play a crucial role in regulating various metabolic processes, including how your body stores fat and uses energy. For example, estrogen can influence fat distribution and storage, while progesterone can affect appetite and cravings. If your hormonal balance is disrupted, it could lead to changes in how your body processes food and stores fat, potentially contributing to weight gain.

Additionally, some individuals may experience changes in appetite or cravings when starting hormonal medications. Even if you believe your caloric intake has remained consistent, hormonal fluctuations can sometimes lead to increased hunger or cravings for certain types of foods, which could inadvertently lead to weight gain.

It's also important to consider the specific type of hormonal medication you are taking. Different medications have varying side effects, and some are more likely to cause weight gain than others. For instance, certain contraceptives and hormone replacement therapies have been associated with weight changes in some users. If you are concerned about the weight gain, it would be beneficial to discuss this with your healthcare provider. They can provide insights into whether the specific medication you are taking is known to cause weight gain and may suggest alternatives if necessary.

In summary, the weight gain you are experiencing could be related to the hormonal medication you have started. It may be due to fluid retention, changes in metabolism, or alterations in appetite. It is advisable to monitor your weight over the next few weeks, as initial weight changes may stabilize as your body adjusts to the medication. If the weight gain continues or if you have other concerns, please consult your healthcare provider for further evaluation and guidance. They can help you determine the best course of action and whether any adjustments to your treatment plan are needed.

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