Side Effects of Mequitazine and Loratadine: What to Know

Q: Side Effects of Mequitazine and Loratadine: What to Know

(Genadine) Mechanism of Action： Loratadine is a potent, long-acting, non-sedating antihistamine of the new tricyclic class, selectively antagonizing peripheral H1 receptors throughout the body. <br>Indications： It is used to relieve symptoms associated with allergic rhinitis, suc

What are the side effects of the medication?

Hello Doctor: I previously visited a dermatologist for skin allergies, and the physician prescribed me mequitazine and genadine tablets (loratadine).
I would like to ask what the side effects of these two medications are.
Will they cause changes in my menstrual cycle? Thank you.

Ann, 20~29 year old female. Ask Date: 2005/08/20

Dr. Wu Zhengfen reply Pharmacology

(Genadine) Mechanism of Action: Loratadine is a potent, long-acting, non-sedating antihistamine of the new tricyclic class, selectively antagonizing peripheral H1 receptors throughout the body.
Indications: It is used to relieve symptoms associated with allergic rhinitis, such as runny nose, nasal congestion, itching, and burning sensations in the eyes, as well as symptoms caused by chronic urticaria and allergic skin conditions.
Dosage: Oral: Adults should take 10 mg once daily.
For children: those weighing over 30 kg should take 10 mg once daily; those weighing 30 kg or less should take 5 mg once daily.
Side Effects: This medication does not have significant side effects.
Precautions: 1.
Safety and efficacy have not been established for children under six years of age.
2.
Safety has not been established for pregnant women.
3.
Caution is advised when administering to breastfeeding women.
Pregnancy and Lactation Precautions: Nursing mothers should take this medication as directed by a physician, as a small amount may pass into breast milk.
It is advisable to avoid breastfeeding during the medication period.
Contraindications: Individuals allergic to this medication.

(Mequitazine) Mechanism of Action: This medication is an antihistamine.
Indications: It is used to treat drug allergies, allergic rhinitis, eczema, urticaria, hay fever, angioedema, and seasonal conjunctivitis.
Dosage: Adults should take 1 tablet twice daily (once in the morning and once in the evening).
Side Effects: Possible side effects include dry mouth, headache, stomach pain, gastrointestinal discomfort, abdominal pain, loss of appetite, diarrhea, constipation, rash, sore throat, drowsiness, fatigue, nausea, chest tightness, palpitations, facial edema, facial flushing, decreased platelet count, and accommodation disorders.
Contraindications: Patients with glaucoma, lower urinary tract obstructive diseases, and those allergic to phenothiazines and similar compounds.
Interactions: The effects of this medication may be enhanced when used in conjunction with central nervous system depressants (such as anesthetics, sedatives, narcotic analgesics, and tranquilizers), antidepressants, MAO inhibitors, and alcohol.
Current data indicates that Genadine and Mequitazine do not cause changes in the menstrual cycle; however, if there are changes, it is advisable to consult a gynecologist.

Reply Date: 2005/08/20

More Info

Mequitazine and Loratadine are both antihistamines commonly prescribed for allergic reactions, such as skin allergies and hay fever. Understanding their side effects and potential impacts on the menstrual cycle is crucial for patients who are considering or currently taking these medications.

Mequitazine
Mequitazine is an antihistamine that is primarily used to treat allergic conditions, including allergic rhinitis, urticaria (hives), and other allergic skin reactions. While it is effective in alleviating symptoms associated with allergies, it does come with a range of potential side effects. Common side effects of Mequitazine include:
- Drowsiness: This is one of the most frequently reported side effects, as Mequitazine can cause sedation.

- Dry mouth: Patients may experience a sensation of dryness in the mouth.

- Gastrointestinal issues: These may include nausea, vomiting, constipation, or diarrhea.

- Headaches: Some individuals may experience headaches while taking this medication.

- Fatigue: General tiredness or lethargy can occur.

- Skin reactions: Rashes or other allergic reactions may develop in some patients.

Regarding the menstrual cycle, there is currently no substantial evidence suggesting that Mequitazine directly affects menstrual regularity or causes changes in the menstrual cycle. However, individual responses to medications can vary, and if you notice any significant changes in your cycle after starting this medication, it is advisable to consult with a healthcare provider.

Loratadine (Genadine)
Loratadine, marketed under various brand names including Genadine, is a second-generation antihistamine that is less sedating compared to first-generation antihistamines. It is primarily used to relieve symptoms of allergic rhinitis and chronic urticaria. The side effects of Loratadine are generally mild and may include:
- Headache: Some users report headaches as a common side effect.

- Fatigue: Although less sedating than Mequitazine, some individuals may still experience fatigue.

- Dry mouth: Similar to Mequitazine, Loratadine can also cause dryness in the mouth.

- Gastrointestinal disturbances: Nausea or upset stomach may occur in some patients.

As with Mequitazine, there is no strong evidence to suggest that Loratadine affects menstrual cycles. Most studies indicate that it does not have a significant impact on hormonal levels or menstrual regularity.

Conclusion
In summary, both Mequitazine and Loratadine are effective antihistamines with a range of potential side effects, primarily related to sedation and gastrointestinal discomfort. Neither medication has been shown to cause significant changes in the menstrual cycle based on current medical literature. However, individual responses can vary, and if you experience any unusual symptoms or changes in your menstrual cycle after starting these medications, it is essential to consult with your healthcare provider for further evaluation and guidance.

If you have any concerns about the medications you are taking or their potential side effects, it is always best to discuss these with your prescribing physician. They can provide personalized advice based on your medical history and current health status.

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