Post-Surgery Medication for Chocolate Cysts: Is 6 Months Necessary? - Obstetrics and Gynecology

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Postoperative pharmacological treatment for chocolate cysts?


Hello, I underwent laparoscopic surgery for a chocolate cyst in July 2005, and the doctor prescribed DANALOL CAPSULE 200MG (DANAZOL) "PURZER" to be taken three capsules daily for six months.
However, I have been taking it for ten weeks now and have experienced many side effects, such as facial swelling, significant weight gain, reduced breast size, hair loss, difficulty sleeping, and a deepened voice.
I have asked friends with similar symptoms, and most of them either conceived without medication or took it for only three months.
I would like to know if it is necessary to take the medication for six months, as I am eager to conceive and have a child.

MMN, 20~29 year old female. Ask Date: 2005/08/31

Dr. Li Guanghan reply Obstetrics and Gynecology


Hello: Surgery for endometriosis followed by six months of medication is a standard treatment protocol.
The use of Danazol may have side effects related to male hormones, which is reasonable, and these effects will resolve after discontinuation.
If the side effects are too severe, it may be considered to adjust the dosage to two pills a day or switch to a GnRH injection every four weeks, which costs approximately 7,000 NTD per injection out-of-pocket.
Hsinchu City Hospital, Department of Obstetrics and Gynecology.

Reply Date: 2005/08/31

More Info


After undergoing laparoscopic surgery for a chocolate cyst, it is understandable to have concerns regarding the post-operative medication regimen, especially when it comes to the duration and potential side effects of the prescribed medication, such as Danazol.
Danazol is a synthetic androgen that is often used to treat endometriosis and conditions like chocolate cysts. It works by suppressing the production of estrogen, which can help reduce the size of cysts and alleviate symptoms. The typical recommendation for Danazol is to take it for a duration of 3 to 6 months, depending on the severity of the condition and the individual patient's response to the medication.
In your case, you have been on Danazol for 10 weeks and are experiencing several side effects, including facial swelling, weight gain, reduced breast size, hair loss, insomnia, and a deeper voice. These side effects are not uncommon with Danazol, as it can cause androgenic effects due to its hormonal activity. It is crucial to communicate these side effects to your healthcare provider, as they may consider adjusting your dosage or switching you to an alternative treatment based on your symptoms and your desire to conceive.

Regarding the necessity of continuing Danazol for the full six months, it is essential to weigh the benefits against the side effects. While some patients may have successfully conceived after a shorter duration of treatment, it is important to understand that stopping the medication prematurely may lead to a recurrence of the cysts or other complications. Therefore, it is advisable to have a detailed discussion with your healthcare provider about your concerns and your desire to conceive. They can provide personalized advice based on your medical history, the size of the cyst, and your overall health.

In terms of fertility, it is possible to conceive after stopping Danazol, but it is crucial to ensure that your body is in the best possible condition for pregnancy. If your doctor believes that the cysts are under control and that the risks of recurrence are low, they may support your decision to stop the medication earlier than planned. However, this decision should be made collaboratively with your healthcare provider, who can monitor your condition closely.

In addition to medication management, consider lifestyle modifications that may support your overall health and fertility. Maintaining a balanced diet rich in fruits, vegetables, whole grains, and lean proteins can help improve your general well-being. Regular exercise, stress management techniques, and avoiding substances like tobacco and excessive alcohol can also contribute positively to your health and fertility.

In conclusion, while the standard recommendation for Danazol is often around six months, individual circumstances can vary significantly. It is crucial to have open communication with your healthcare provider about your symptoms, side effects, and desire to conceive. They can help you navigate the best course of action tailored to your specific situation, ensuring both your health and your fertility goals are prioritized.

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