Does microalbuminuria require treatment?
Hello Doctor: My daughter is currently 10 years old and occasionally wets the bed at night (about 3-4 times a month).
After visiting the hospital for examination, it was found that she has mild hydronephrosis in both kidneys, but her kidney ultrasound and routine urinalysis were normal.
She also underwent a "urinary reflux test," which was normal.
However, in recent biochemical tests of her urine conducted in June and September, trace amounts of proteinuria were detected, although her blood pressure is normal (another physician previously conducted routine urinalysis but did not further investigate the trace proteinuria).
Since June, the doctor has prescribed pentoxifylline (100 mg) at half a tablet twice daily, as she experienced nausea when taking a full tablet.
During a follow-up visit on September 24, there were still trace amounts of proteinuria (and the value seems to have increased from 70 to 83), which worries me.
I am unsure whether to continue the medication or seek another physician's opinion.
Given that her kidneys are not functioning well, will long-term use of this medication worsen her kidney condition? Is medication necessary for trace proteinuria, or is regular follow-up sufficient? Besides taking pentoxifylline, she is also taking Imipramine once daily before bedtime to treat her nocturnal enuresis, which has improved her bedwetting.
Thank you for taking the time to address my concerns, and I wish you all the best!
Ms. Huang, 40~49 year old female. Ask Date: 2005/09/30
Dr. Yang Jun reply Internal Medicine
Hello: In response to your question, your 10-year-old daughter has been found to have trace proteinuria, which is most commonly caused by minimal change disease in children.
It is advisable to consult a pediatric nephrologist for further evaluation.
Pentoxifylline has a specific effect in reducing proteinuria in nephrology treatment and should be continued to alleviate and treat the proteinuria, thereby achieving the desired outcomes in kidney disease management.
Additionally, it is important to maintain a diet low in salt and protein to support prevention and treatment efforts.
Reply Date: 2005/09/30
More Info
Mild proteinuria in children can be a concerning issue for parents, especially when it is discovered during routine check-ups or due to other symptoms such as bedwetting. In your case, your 10-year-old daughter has been diagnosed with mild proteinuria, and you are understandably worried about the implications of this condition and the treatment options available.
Firstly, it is essential to understand what proteinuria means. Proteinuria refers to the presence of excess protein in the urine, which can be a sign of kidney dysfunction. In children, mild proteinuria is often not a cause for alarm, especially if it is isolated and not accompanied by other symptoms such as high blood pressure, swelling, or significant changes in kidney function. In many cases, it can be transient and resolve on its own.
Your daughter's situation, where she has mild proteinuria but normal blood pressure and no significant findings on imaging studies, suggests that this may not be a severe issue. However, the fact that her protein levels have increased slightly over time does warrant further monitoring and evaluation. The use of pentoxifylline, which is aimed at reducing proteinuria, is a common approach, but it is crucial to weigh the benefits against any side effects, such as nausea, which you mentioned she experienced.
Regarding your concerns about whether to continue the medication or seek a second opinion, it is always a good idea to discuss these concerns with her healthcare provider. If the proteinuria persists or worsens, or if new symptoms develop, further investigation may be necessary. This could include additional blood tests, urine tests, or even a kidney biopsy if indicated, to rule out any underlying kidney disease.
In terms of management, regular follow-up appointments are essential. Monitoring her kidney function and protein levels over time will help determine if the proteinuria is indeed a benign condition or if it requires more aggressive treatment. Dietary modifications, such as a low-salt and balanced diet, can also be beneficial in managing kidney health.
As for the use of Imipramine for bedwetting, it is good to hear that this has shown improvement. Bedwetting is common in children and can sometimes be associated with underlying issues, including urinary tract infections or bladder dysfunction. If the bedwetting continues, it may be worth discussing further treatment options with her pediatrician or a specialist in pediatric urology.
In summary, while mild proteinuria can be concerning, it is often manageable with careful monitoring and appropriate treatment. It is essential to maintain open communication with your daughter's healthcare team, ensuring that any changes in her condition are promptly addressed. Regular check-ups and a proactive approach to her health will help ensure the best outcomes for her kidney function and overall well-being.
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