Orgametril: How It Affects Your Menstrual Cycle and Ovulation

Q: Orgametril: How It Affects Your Menstrual Cycle and Ovulation

Hello： 1. <br>Orgametril (generic name： Lynestrenol) is a progestin. <br>The use of progestins varies, leading to different functions such as inducing menstruation, delaying menstruation, suppressing ovulation, treating dysfunctional uterine bleeding, and managing endometriosis.

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I last had my menstrual period on August 28, and today is October 5.
My period has not arrived yet; although it is only a week late, my cycles usually come early rather than being delayed for so many days.
Therefore, I went to the gynecologist today to take a pregnancy test, which came back negative.
However, the doctor prescribed me a medication called "Orgametril." The doctor mentioned that this is a medication to induce menstruation.
I found some information online stating that this medication can strongly affect the endometrium during the secretory phase and can inhibit ovulation and the onset of menstruation.
So, I would like to ask the doctor: I want to induce my period, but how can this medication, which inhibits the onset of menstruation, help me in this situation? Additionally, I have noticed that my menstrual cycles have shortened over the past year, averaging around 28 days, whereas a year ago, my cycles were typically over 30 days.
Does a decrease in progesterone also affect the length of the menstrual cycle? Thank you, doctor.
Thank you.

Xiao Mei, 20~29 year old female. Ask Date: 2005/10/05

Dr. Li Guanghan reply Obstetrics and Gynecology

Hello: 1.
Orgametril (generic name: Lynestrenol) is a progestin.
The use of progestins varies, leading to different functions such as inducing menstruation, delaying menstruation, suppressing ovulation, treating dysfunctional uterine bleeding, and managing endometriosis.
2.
The length of the menstrual cycle is determined by whether ovulation occurs, when ovulation occurs, and the adequacy of the corpus luteum's secretion of progesterone after ovulation.
If this function is insufficient, the luteal phase will be shorter, resulting in an overall shorter menstrual cycle.
Hsinchu Hospital, Department of Obstetrics and Gynecology.

Reply Date: 2005/10/05

More Info

Orgametril, which contains the active ingredient norethisterone, is a synthetic progestogen used to treat various menstrual disorders. Understanding how it affects your menstrual cycle and ovulation is crucial, especially in your case where you are experiencing a delay in your menstrual period.

Mechanism of Action
Orgametril works primarily by mimicking the effects of the natural hormone progesterone. It plays a significant role in regulating the menstrual cycle and preparing the endometrium (the lining of the uterus) for potential implantation of a fertilized egg. Here’s how it affects your menstrual cycle:
1. Endometrial Regulation: Orgametril promotes the secretory phase of the endometrium, which means it prepares the uterine lining for a possible pregnancy. If pregnancy does not occur, the hormone levels drop, leading to menstruation.

2. Ovulation Suppression: In some cases, Orgametril can inhibit ovulation, which is the release of an egg from the ovary. This is particularly useful in conditions where ovulation is irregular or absent.

3. Cycle Regulation: By providing a consistent level of progestogen, Orgametril can help regulate menstrual cycles, making them more predictable. This is especially beneficial for women who experience irregular periods.

Why Your Doctor Prescribed Orgametril
In your situation, where your menstrual cycle has been irregular and you have experienced a delay, your doctor likely prescribed Orgametril to help induce menstruation. Although it can suppress ovulation, it can also help to regulate the menstrual cycle by prompting the shedding of the endometrial lining, which may not have occurred due to hormonal imbalances.

Concerns About Menstrual Cycle Changes
You mentioned that your menstrual cycles have been shortening over the past year, from around 30 days to approximately 28 days. This change can be attributed to several factors, including hormonal fluctuations, stress, lifestyle changes, or underlying health conditions.
1. Luteal Phase Deficiency: A reduction in progesterone levels can lead to a shorter luteal phase (the time between ovulation and the start of menstruation). This can result in irregular cycles and may affect fertility.

2. Hormonal Imbalances: Conditions such as polycystic ovary syndrome (PCOS), thyroid disorders, or other hormonal imbalances can lead to changes in menstrual cycle length and regularity.

Conclusion
In summary, Orgametril is prescribed to help regulate your menstrual cycle and induce menstruation, particularly when there are delays. While it can suppress ovulation, its primary role in your case is to stabilize the endometrial lining and promote menstruation. If you have concerns about your menstrual cycle, including its length and regularity, it is essential to discuss these with your healthcare provider. They may recommend further evaluation to rule out any underlying conditions that could be affecting your hormonal balance and menstrual health.

If you continue to experience irregularities or have additional symptoms, consider following up with your doctor for further assessment and potential treatment options. Regular monitoring and open communication with your healthcare provider are key to managing your menstrual health effectively.

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