Why Isn't My Hemoglobin Rising Despite Taking Iron Supplements? - Oncology

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Why is hemoglobin (Hb) still not increasing after taking iron supplements?


Hello, my hemoglobin (Hb) has been consistently around 9.5.
After going to the hospital for a check-up, I found out that I have iron deficiency, but even after taking iron supplements for a while, my Hb is still around 9.5.
Why is that? A traditional Chinese medicine practitioner mentioned that my gastrointestinal health is not very good.
Could poor gastrointestinal health affect the absorption of iron supplements? Or could I have a more serious illness?

bu dong, 20~29 year old female. Ask Date: 2005/10/12

Dr. Fan Sheng reply Oncology


1.
It is possible that the dosage of iron supplements is insufficient or that there is ongoing blood loss.
Gastrointestinal bleeding, urinary tract bleeding, and excessive menstrual bleeding in females all require examination and treatment.

2.
The diagnosis can be further confirmed; measuring serum ferritin is more accurate than measuring serum iron levels.
Chronic inflammation, tuberculosis, abscesses, cancer, and autoimmune diseases can all lead to low serum iron levels but high ferritin levels in anemia.

3.
The possibility of congenital anemia, such as thalassemia, should also be considered.

Reply Date: 2005/10/12

More Info


When dealing with persistent low hemoglobin levels despite iron supplementation, several factors must be considered to understand why your hemoglobin (Hb) remains around 9.5 g/dL. This situation can be frustrating, especially when you are actively trying to address a diagnosed iron deficiency.

Firstly, it is essential to recognize that iron supplementation can take time to show significant effects on hemoglobin levels. Generally, it may take several weeks to months of consistent iron intake before a noticeable increase in hemoglobin is observed. The standard recommendation is to continue iron supplementation for at least three months before reassessing hemoglobin levels. If you have only been on iron supplements for a short duration, it may simply be too early to see the desired results.

Secondly, the dosage of iron you are taking could be insufficient. Iron supplements come in various forms and dosages, and your healthcare provider may need to adjust your prescription based on your specific needs. Additionally, the type of iron supplement matters; ferrous sulfate is commonly recommended due to its higher bioavailability compared to other forms.

Another critical factor is the absorption of iron, which can be significantly affected by gastrointestinal health. If you have gastrointestinal issues, such as gastritis, irritable bowel syndrome, or other conditions that affect the gut lining, this could hinder the absorption of iron. Conditions like celiac disease or inflammatory bowel disease can also lead to malabsorption of nutrients, including iron. Therefore, if you suspect that your gastrointestinal health is poor, it would be wise to consult a gastroenterologist for further evaluation.

Moreover, chronic blood loss is a common cause of iron deficiency anemia. If you are experiencing heavy menstrual periods or gastrointestinal bleeding (which may not always be apparent), this could lead to ongoing iron depletion despite supplementation. It is crucial to investigate potential sources of chronic blood loss, which may include endometrial issues in women or gastrointestinal conditions like ulcers or polyps.

Additionally, other medical conditions can contribute to low hemoglobin levels. For instance, chronic inflammation, kidney disease, or certain malignancies can lead to anemia of chronic disease, where iron stores may be adequate, but the body is unable to utilize them effectively. In such cases, ferritin levels may appear normal or even elevated, while hemoglobin remains low. Therefore, further testing, including serum ferritin, total iron-binding capacity (TIBC), and possibly a bone marrow biopsy, may be warranted to clarify the underlying cause of your anemia.

Lastly, lifestyle factors such as diet, hydration, and overall health can also play a role. A diet low in iron-rich foods (like red meat, beans, lentils, and fortified cereals) can contribute to ongoing deficiencies. Additionally, if you are not adequately hydrated or are experiencing significant physical stress, this can exacerbate symptoms of anemia, including fatigue and dizziness.

In summary, if your hemoglobin levels are not rising despite taking iron supplements, it is essential to consider the following: the adequacy of the iron dosage, the potential for gastrointestinal absorption issues, the possibility of chronic blood loss, and the presence of other underlying medical conditions. It is advisable to follow up with your healthcare provider for a comprehensive evaluation and possibly further testing to determine the best course of action for your specific situation.

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