Does Hypertension Medication Increase Diabetes Risk in Seniors? - Internal Medicine

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Do antihypertensive medications cause diabetes?


Hello! I am 72 years old and have been on antihypertensive medication for over a decade.
Recently, I had a check-up, and my blood sugar was 198, with the presence of glucose in my urine.
Is this diabetes caused by high blood pressure, or could it be a result of the antihypertensive medication Tenormin (which I have been taking for three months)? At the time of the test, I also had dental inflammation; could this affect my blood sugar levels? Should I start taking medication to lower my blood sugar? Thank you!

wu, 70~79 year old female. Ask Date: 2005/12/17

Dr. Shi Guangzhong reply Internal Medicine


There are many causes of diabetes, and it cannot be definitively determined whether hypertension or medication is the cause.
In any case, a blood sugar level of 198 needs to be controlled.
Regarding whether dental inflammation on the day of testing affects blood sugar levels, for a diabetic patient, any illness or inflammatory response in the body will lead to an increase in blood sugar.
Whether medication is necessary should be assessed based on the patient's dietary habits and exercise routine.
If dietary changes can improve blood sugar levels, with pre-meal levels below 120 and post-meal levels maintained below 160 two hours after eating, then blood sugar can be controlled through diet and exercise without the need for medication.

Reply Date: 2005/12/17

More Info


Hypertension and diabetes are two common health conditions that often coexist, particularly in older adults. Your question about whether hypertension medication, specifically Tenormin (Atenolol), could increase the risk of diabetes is quite relevant, especially given your recent blood sugar levels and urinary glucose findings.

Firstly, it is important to understand that while hypertension itself does not directly cause diabetes, there is a well-established link between the two conditions. Individuals with hypertension are at a higher risk of developing type 2 diabetes, primarily due to shared risk factors such as obesity, physical inactivity, and poor dietary habits. Additionally, the physiological stress associated with hypertension can lead to insulin resistance, which is a precursor to diabetes.

Regarding the use of antihypertensive medications, some studies have suggested that certain classes of blood pressure medications, particularly beta-blockers like Tenormin, may be associated with an increased risk of developing diabetes. This is thought to be due to their potential effects on glucose metabolism. Beta-blockers can impair insulin sensitivity and may lead to weight gain, both of which can contribute to an increased risk of diabetes. However, the overall risk is generally considered to be low, and the benefits of controlling hypertension often outweigh the potential risks of developing diabetes.

In your case, the recent blood sugar level of 198 mg/dL is concerning, as it indicates hyperglycemia. The presence of glucose in your urine (glycosuria) further suggests that your blood sugar levels have been elevated for some time. It is crucial to determine whether this hyperglycemia is a result of the hypertension itself, the medication, or other factors such as your dental infection. Infections can indeed cause temporary increases in blood sugar levels due to the stress response and the release of stress hormones like cortisol, which can raise blood glucose levels.

Given your situation, it is advisable to consult with your healthcare provider about the following steps:
1. Medication Review: Discuss the possibility of switching from Tenormin to another class of antihypertensive medication that may have a lower risk of affecting blood sugar levels. There are several alternatives, such as ACE inhibitors, ARBs, or calcium channel blockers, which may be more suitable for you.

2. Diabetes Testing: Since your blood sugar is elevated, it would be prudent to conduct further testing to confirm whether you have developed diabetes. This may include an HbA1c test, which provides an average blood sugar level over the past two to three months. The diagnostic criteria for diabetes include an HbA1c of 6.5% or higher, fasting plasma glucose of 126 mg/dL or higher, or a 2-hour plasma glucose of 200 mg/dL or higher during an oral glucose tolerance test.

3. Management of Dental Infection: Addressing your dental infection is also important, as it could be contributing to your elevated blood sugar levels. Once the infection is treated, it may help stabilize your blood glucose levels.

4. Lifestyle Modifications: Regardless of medication changes, adopting a healthy lifestyle can significantly impact both hypertension and blood sugar levels. This includes a balanced diet, regular physical activity, weight management, and stress reduction techniques.

5. Monitoring: Regular monitoring of your blood sugar levels will be essential to assess how your body is responding to any changes in medication or lifestyle.

In conclusion, while there is a potential link between hypertension medications and increased diabetes risk, it is essential to consider all factors at play, including your overall health, lifestyle, and any infections. Working closely with your healthcare provider will help you navigate these concerns and develop an appropriate management plan.

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