Delayed Menstrual Cycle After Medication: What to Do Next? - Obstetrics and Gynecology

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I took the medication, but my menstrual cycle still hasn't started?


Hello, doctor.
I would like to ask about my menstrual cycle, which usually starts on the 20th of each month.
However, this December, it was delayed.
I have no signs of pregnancy and have taken a pregnancy test.
Later, I visited a gynecologist and was prescribed Clomiphene.
It has been one or two days since I started taking it, but my period still hasn't arrived, and I am experiencing breast tenderness.

Vivian, 20~29 year old female. Ask Date: 2005/12/23

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, Miss: Generally, after stopping menstrual induction medication, it takes about 3-4 days for menstruation to occur.
Therefore, if your period hasn't arrived in one or two days, you may wait a little longer.
If your period still hasn't started after a week of stopping the medication, you should follow up with a gynecologist.
Breast tenderness may indicate that your period is approaching; you can wait and see.

Reply Date: 2005/12/23

More Info


Delayed menstrual cycles can be a source of concern for many women, especially when they are typically regular. In your case, it seems that your menstrual cycle, which usually arrives on the 20th of each month, has been delayed this December. You have taken a pregnancy test that returned negative, which is a good first step in ruling out pregnancy as a cause for the delay. Additionally, you mentioned that you have started taking medication prescribed by your gynecologist, specifically Clomiphene Citrate (commonly referred to as "崔經" in Chinese), which is often used to induce ovulation.

There are several factors that could contribute to a delayed menstrual cycle, even when pregnancy is ruled out. Stress, significant weight changes, hormonal imbalances, and certain medical conditions can all affect the regularity of your cycle. Clomiphene Citrate is typically used to help with ovulation issues, and it can sometimes take a few days to a couple of weeks to see its effects on your menstrual cycle.

Here are some steps you can consider taking next:
1. Continue Monitoring: Keep track of any additional symptoms you may experience, such as changes in breast tenderness, abdominal discomfort, or any other unusual signs. This information can be helpful for your healthcare provider.

2. Follow Up with Your Doctor: Since you have already consulted with a gynecologist and started medication, it is important to keep them informed about your situation. If your menstrual cycle does not start within a few days after taking the medication, or if your symptoms worsen, you should reach out to your doctor for further evaluation.

3. Consider Lifestyle Factors: Evaluate any recent changes in your lifestyle that may contribute to stress or hormonal changes. This includes changes in diet, exercise, sleep patterns, or emotional stressors. Sometimes, making adjustments in these areas can help regulate your cycle.

4. Be Patient: Hormonal medications like Clomiphene Citrate can take some time to work. It may take a few cycles for your body to respond adequately to the treatment. Patience is key, but if you have concerns or if your symptoms persist, do not hesitate to seek further medical advice.

5. Explore Other Causes: If your menstrual cycle remains irregular or if you experience other concerning symptoms, your doctor may recommend additional tests to rule out conditions such as polycystic ovary syndrome (PCOS), thyroid disorders, or other hormonal imbalances.

In summary, while a delayed menstrual cycle can be concerning, it is important to approach the situation with a clear plan. Continue to monitor your symptoms, maintain open communication with your healthcare provider, and consider lifestyle factors that may be influencing your cycle. If necessary, further evaluation can help identify any underlying issues that may need to be addressed.

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