Why Cold Medicine Might Make You Feel Worse: Reactions - Internal Medicine

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Taking cold medicine may make you feel worse?


Hello Doctor, I would like to ask you about a friend of mine who recently caught a cold and has been coughing.
He went to a hospital to get cold medication, but every time he takes the medicine, he feels very uncomfortable, even more so than when he has the cold.
He experiences full-body shaking and weakness.
However, if he doesn't take the medication, his cough becomes very severe.
I would like to know if this is related to his constitution.
Does this mean he won't be able to take medication for colds in the future? Is there any way to improve this situation? Thank you for your response.

Tong Yi Bao Jian, 20~29 year old female. Ask Date: 2006/02/07

Dr. Zeng Guosen reply Internal Medicine


Hello: A mild cold does not necessarily require medication.
However, if symptoms persist for too long or are severe, you should seek medical attention.
Common cold medications can have side effects, and what you are describing is likely a side effect.
It is advisable to return for a follow-up and inform your doctor; adjusting the prescription should alleviate the symptoms.
Wishing you good health! Sincerely, Dr.
Tseng Kuo-Sen, Internal Medicine.

Reply Date: 2006/02/07

More Info


When it comes to cold medications, it's not uncommon for some individuals to experience adverse reactions that can make them feel worse than the illness itself. Your friend's experience of feeling extremely uncomfortable after taking cold medicine, including symptoms like shaking and weakness, can be attributed to several factors, including individual body chemistry, the specific ingredients in the medication, and potential drug interactions.

Firstly, it's important to understand that cold medications often contain a combination of active ingredients designed to alleviate symptoms such as congestion, cough, and fever. Common components include antihistamines, decongestants, cough suppressants, and pain relievers. While these ingredients can be effective for many, they can also cause side effects, especially in sensitive individuals.

For instance, antihistamines, which are often included in cold medications, can cause drowsiness, dizziness, and in some cases, paradoxical reactions such as increased agitation or restlessness. This could explain your friend's experience of feeling shaky or weak after taking the medication. Additionally, some decongestants can lead to increased heart rate and anxiety, which might contribute to feelings of discomfort.

Moreover, if your friend is taking other medications or has underlying health conditions, there could be interactions that exacerbate these side effects. For example, combining cold medications with certain antidepressants or anti-anxiety medications can lead to increased sedation or other adverse effects. It's crucial for individuals to disclose all medications they are taking to their healthcare provider to avoid such interactions.

Another factor to consider is individual body chemistry. Some people may have a heightened sensitivity to certain medications, leading to more pronounced side effects. This can be due to genetic factors, existing health conditions, or even lifestyle factors such as diet and stress levels. If your friend has a history of adverse reactions to medications, it might be wise for them to consult with a healthcare professional about alternative treatments.

If your friend finds that cold medications consistently make them feel worse, they should consider discussing this with their healthcare provider. There are various non-pharmacological approaches to managing cold symptoms, such as staying hydrated, using saline nasal sprays, and employing steam inhalation to relieve congestion. Additionally, rest and proper nutrition can support the immune system during illness.

In some cases, a healthcare provider may recommend a different formulation of cold medication or suggest over-the-counter options that might be better tolerated. For instance, some formulations are designed to be less sedating or have fewer side effects. It may also be beneficial for your friend to try medications that target specific symptoms rather than a combination product, which can sometimes reduce the likelihood of experiencing adverse effects.

In conclusion, while cold medications can be effective for many people, they are not without their potential downsides. Your friend's experience highlights the importance of personalized medicine, where treatments are tailored to the individual's unique needs and responses. Encouraging your friend to seek guidance from a healthcare professional can help them find a more suitable approach to managing their cold symptoms, ensuring they can recover without feeling worse in the process.

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