Adrenal Issues: Weight Gain and Health Concerns - Internal Medicine

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~Adrenal gland issues~


Hello Doctor: Last week, I visited the endocrinology department at Kaohsiung Medical University because I gained 25 kg in a year.
I used to weigh 57 kg, and now I weigh 82 kg.
I eat very little and do not feel hungry.
The doctor suspects that there may be an issue with my adrenal glands and mentioned that surgery might be necessary.
He ordered a head X-ray, a kidney scan, and blood tests.
I have a follow-up appointment on October 15 to discuss the results.
However, during the kidney scan, the doctor mentioned that I have fatty liver disease.
Additionally, my gynecological examination revealed polycystic ovarian syndrome, but I haven't been eating much.

Could you please tell me if surgery will help me lose weight? What are the causes of these conditions? If I do not have surgery and take medication, how effective will that be for my condition? Is fatty liver disease only associated with overweight individuals? If I lose weight, will the fatty liver issue resolve? Thank you for your help.

Xiao Ying, 10~19 year old female. Ask Date: 2001/10/04

Dr. Hong Hongchang reply Internal Medicine


Fatty liver is caused by endocrine disorders, hyperlipidemia, alcohol consumption, or viral hepatitis.
Therefore, it may be necessary to treat the underlying conditions, and it is hoped that follow-up can be conducted in the gastroenterology and hepatology department.

Reply Date: 2001/10/04

More Info


Hello! It sounds like you are going through a challenging time with your health, particularly regarding your significant weight gain and the potential adrenal issues that your doctor suspects. Let’s break down your concerns and provide some insights based on medical knowledge.

Firstly, gaining 25 kg (approximately 55 lbs) in a year, especially when you feel you are eating very little and not feeling hungry, is indeed concerning. This kind of weight gain can be attributed to various factors, including hormonal imbalances, metabolic disorders, or even psychological factors. Your doctor’s suspicion regarding adrenal issues is valid, as conditions like Cushing's syndrome, which is caused by excess cortisol production from the adrenal glands, can lead to rapid weight gain, particularly in the abdominal area, and other symptoms such as fatigue, mood changes, and skin changes.

The tests your doctor has ordered, including imaging studies and blood tests, are essential for diagnosing any underlying conditions. The presence of fatty liver (steatosis) and polycystic ovary syndrome (PCOS) can also be linked to metabolic syndrome, which is often associated with obesity. Fatty liver disease can occur in individuals who are not necessarily overweight, especially if there are other metabolic issues at play, such as insulin resistance.

Regarding your question about surgery, it depends on the specific diagnosis. If your weight gain is due to an adrenal tumor or another condition that can be surgically corrected, then surgery might help in normalizing your hormone levels and potentially lead to weight loss. However, if the weight gain is primarily due to lifestyle factors or other non-surgical conditions, surgery may not be necessary or effective.

If surgery is not an option, medication can help manage symptoms and underlying conditions. For instance, if your adrenal glands are producing too much cortisol, medications can help regulate hormone levels. The effectiveness of medication varies from person to person, and it often requires close monitoring and adjustments by your healthcare provider.

As for fatty liver disease, it is not exclusively a condition for overweight individuals. It can occur in those with normal weight, particularly if they have metabolic syndrome or insulin resistance. Weight loss is one of the most effective treatments for fatty liver disease. Losing even a small percentage of your body weight (around 5-10%) can significantly improve liver health and reduce fat accumulation in the liver.

In summary, addressing your weight gain and health concerns involves a comprehensive approach that includes:
1. Follow-Up with Your Doctor: Continue to work closely with your healthcare provider to understand the results of your tests and the best course of action.

2. Lifestyle Modifications: If possible, incorporate a balanced diet and regular physical activity into your routine. Even gentle exercises, like walking or swimming, can be beneficial.

3. Medication Management: If prescribed, adhere to your medication regimen and discuss any side effects or concerns with your doctor.

4. Monitoring and Support: Regular check-ups and possibly working with a nutritionist or a weight management program can provide additional support.

5. Mental Health: Consider speaking with a mental health professional if you feel overwhelmed. Emotional well-being is crucial in managing physical health.

Remember, you are not alone in this journey, and with the right support and treatment, you can work towards improving your health. Best wishes for your upcoming appointments and your path to better health!

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