Proteinuria: Is 500g Serious and Could It Cause Hair Loss? - Urology

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Urinary protein


A 24-hour urine protein result of 500 mg is considered significant and may indicate a condition such as nephrotic syndrome or other kidney issues.
The medication you mentioned, Shanxi Duo, could potentially have side effects, including hair loss.
It is important to consult with your healthcare provider to determine whether the elevated urine protein levels are related to your hair loss or if it is a side effect of the medication.

AMY, 40~49 year old female. Ask Date: 2006/03/27

Dr. Chen Qiunan reply Urology


Hello, a 24-hour urine protein level of 500 grams is a serious condition.
The side effects of taking 1 gram of mycophenolate mofetil (250 mg per tablet) are not severe.
Common side effects include diarrhea, vomiting, and leukopenia; hair loss is not very common.
You may also be taking other immunosuppressants, such as Cyclophosphamide (brand name Endoxan) and Azathioprine (brand name Imuran), which can make hair loss more likely.
Thank you for your inquiry, and I wish you health and happiness.

Reply Date: 2006/03/27

More Info


Proteinuria, or the presence of excess protein in the urine, can be a significant indicator of underlying health issues, particularly related to kidney function. A 24-hour urine protein result of 500 grams is indeed considered very serious and warrants immediate medical attention. Normal protein levels in urine should be less than 150 mg per day. When protein levels exceed this threshold, it can indicate conditions such as nephrotic syndrome, glomerulonephritis, or other kidney diseases.

The kidneys play a crucial role in filtering waste and excess substances from the blood while retaining essential proteins. When the kidneys are damaged or diseased, they may allow proteins, such as albumin, to leak into the urine. This loss of protein can lead to a variety of complications, including edema (swelling), increased risk of infections, and nutritional deficiencies.

Regarding your concern about hair loss, there is a potential connection between proteinuria and hair health. Hair is primarily made of a protein called keratin, and adequate protein intake is essential for maintaining healthy hair growth. If your body is losing significant amounts of protein through the urine, it may lead to a deficiency that could contribute to hair thinning or loss. Additionally, the underlying conditions causing proteinuria may also affect hair health. For instance, systemic diseases like diabetes or autoimmune disorders can lead to hair loss as a secondary effect.

As for the medications you mentioned, such as "山喜多" (likely referring to a specific medication), it is essential to consult with your healthcare provider regarding any potential side effects, including hair loss. Some medications can indeed have side effects that affect hair growth, either through hormonal changes or other mechanisms.
In summary, a 24-hour urine protein level of 500 grams is a serious condition that requires further evaluation and management by a healthcare professional. It is crucial to address the underlying cause of the proteinuria to prevent further complications. Additionally, if you are experiencing significant hair loss, it is advisable to discuss this with your doctor, who may recommend a comprehensive approach that includes dietary adjustments, potential supplementation, and possibly a referral to a dermatologist or a specialist in hair loss.

In the meantime, ensure you are consuming a balanced diet rich in proteins, vitamins, and minerals that support hair health. Foods high in protein, such as lean meats, fish, eggs, dairy products, legumes, and nuts, can help provide the necessary building blocks for hair growth. Furthermore, managing stress levels, maintaining a healthy lifestyle, and avoiding harsh hair treatments can also contribute positively to hair health.

Ultimately, addressing both the proteinuria and the hair loss in tandem will provide a more holistic approach to your health concerns. Regular follow-ups with your healthcare provider will be essential in monitoring your kidney function and overall health.

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