Abnormal Liver Function in Chronic Hepatitis B Patients

Hepatitis B e-antigen negative, e-antibody positive, but liver function is abnormal?

Hello, I am a carrier of hepatitis B.
Two years ago, my HBeAg was negative and my HBeAb was positive, but recently my liver function has been abnormal (over 400), and my HBV DNA is 77,754,500.
I do not have hepatitis C or D.
My doctor has suggested that I take HepaNavi.

1.
Can I take HepaNavi given my condition?
2.
Is a liver biopsy required to apply for insurance coverage for HepaNavi?
3.
If I take HepaNavi, how long will the treatment last?
4.
Are there any hospitals where I can apply for insurance coverage for HepaNavi without needing a liver biopsy?
5.
There is a general aversion to liver biopsies; is a liver biopsy really that dangerous?
I apologize for the many questions, and thank you for your response!

Tūbiàn, 30~39 year old female. Ask Date: 2006/05/15

Dr. Xu Jinchuan reply Gastroenterology and Hepatology

Hello! If you are a mutant strain and want to receive health insurance coverage, a liver biopsy is required.
If the health insurance coverage is for 12 to 18 months without a liver biopsy, it is actually a well-established procedure that is performed daily.
Moreover, a careful assessment is necessary before the procedure, so it should be safe to proceed.

Reply Date: 2006/05/15

More Info

Hello! Thank you for your questions regarding your condition as a chronic Hepatitis B carrier. Let’s break down your concerns one by one.

1. Can you take Hepatitis B medication (肝安能)?
Based on your situation, where you have elevated liver enzymes (over 400) and a high HBV DNA level (77,754,500), it is crucial to manage your Hepatitis B effectively. The medication you mentioned,肝安能 (which is likely a reference to antiviral therapy), can be appropriate for your condition. However, the specific choice of medication should be made by your healthcare provider based on a comprehensive evaluation of your liver function, viral load, and overall health status. It’s essential to have a thorough discussion with your doctor about the potential benefits and risks of starting this treatment.

2. Is a liver biopsy necessary to apply for insurance coverage for肝安能?
In many healthcare systems, a liver biopsy is often required to assess the degree of liver damage (fibrosis or cirrhosis) before starting antiviral therapy, especially if you are seeking insurance coverage for the medication. However, some clinics may allow for alternative assessments, such as non-invasive tests (like FibroScan or blood tests that estimate liver stiffness) to evaluate liver health without the need for a biopsy. It’s best to consult with your healthcare provider or the insurance company directly to understand their specific requirements.

3. How long is the treatment duration for肝安能?
The duration of treatment with antiviral medications for Hepatitis B can vary significantly depending on individual circumstances. Generally, treatment may last for at least one year, and in some cases, it may be a long-term therapy, possibly for life, especially if the virus remains active. Regular monitoring of liver function and HBV DNA levels will guide your healthcare provider in determining the appropriate length of treatment.

4. Are there hospitals that allow for肝安能 coverage without a liver biopsy?
Some hospitals or clinics may offer alternative assessments that could qualify for insurance coverage without requiring a liver biopsy. It’s advisable to reach out to various healthcare facilities in your area and inquire about their policies regarding Hepatitis B treatment and insurance coverage. They may have protocols in place that allow for non-invasive assessments.

5. Is a liver biopsy really dangerous?
A liver biopsy is generally considered a safe procedure, but like any medical intervention, it carries some risks. Potential complications can include bleeding, infection, or discomfort at the biopsy site. The risk of serious complications is low, but it’s understandable that many people feel apprehensive about the procedure. Discussing your concerns with your healthcare provider can help you weigh the risks and benefits and explore alternative options if you are uncomfortable with a biopsy.

In summary, managing chronic Hepatitis B requires careful monitoring and treatment. It’s essential to work closely with your healthcare provider to determine the best course of action for your specific situation. Regular follow-ups and open communication about your concerns will help ensure that you receive the best care possible. If you have further questions or need clarification, don’t hesitate to reach out to your healthcare team. Wishing you the best in your health journey!

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