Genital Warts: Treatment Options and Recommendations - Urology

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Genital warts (commonly known as cauliflower)


Hello, Dr.
Hsu.
I have three 3mm condylomata acuminata (commonly known as genital warts) on the surface of my penis and foreskin.
The doctor only prescribed me 5-FU cream to apply twice a day for two weeks.
Today is the third day of self-application.
Should I use Aldara (imiquimod), as it might be more effective in eradicating the warts? Would using podophyllin or interferon be faster? My wife does not have any visible condylomata acuminata.
Should she be checked? Please give me your advice.
Thank you.

tim, 40~49 year old female. Ask Date: 2006/06/17

Dr. Xu Weikai reply Urology


Tim: Hello, Podophyllin may have good effects, but it may not necessarily work faster.
Generally, it is recommended that anyone who has had sexual contact should undergo screening.
This is a response from Dr.
Hsu Wei-Kai, Director of Urology at Taitung Hospital, Department of Health, Executive Yuan.

Reply Date: 2006/06/17

More Info


Genital warts, caused by certain strains of the human papillomavirus (HPV), are a common sexually transmitted infection. The treatment options for genital warts vary, and the choice of treatment often depends on the size, number, and location of the warts, as well as patient preference and medical history.


Treatment Options
1. Topical Treatments:
- 5-Fluorouracil (5FU) Cream: This is a chemotherapy agent that can be applied directly to the warts. It works by interfering with the growth of abnormal cells. Your doctor has prescribed this for you to use twice daily for two weeks. It is important to follow the prescribed regimen and monitor for any side effects, such as irritation or redness.

- Podophyllin: This is a resin derived from the Podophyllum plant and is used as a topical treatment. It is effective in destroying wart tissue but should be applied by a healthcare professional due to potential side effects and the need for proper application.

- Imiquimod (Aldara): This is an immune response modifier that can help the body fight the HPV infection. It is applied topically and may be more effective for some patients. It is known to stimulate the immune system, which can help eliminate the warts more effectively than some other topical treatments.

2. Injections:
- Interferon: This is an injectable medication that can help boost the immune response against the virus. It is not commonly used as a first-line treatment for genital warts but may be considered in persistent cases.

3. Surgical Options:
- Cryotherapy: This involves freezing the warts with liquid nitrogen, which causes them to fall off.

- Electrosurgery: This method uses electrical currents to destroy the warts.

- Laser Therapy: This is used for larger or more difficult-to-treat warts.


Recommendations
- Follow-Up: Since you are currently using 5FU cream, it is essential to follow up with your healthcare provider after the treatment period to assess the effectiveness and determine if further treatment is necessary.

- Partner Screening: Even if your wife does not show visible signs of genital warts, it is advisable for her to undergo screening. HPV can be asymptomatic, and she may carry the virus without showing symptoms. Regular gynecological check-ups and Pap smears can help monitor her health.

- Safe Practices: To reduce the risk of transmission, consider using condoms, although they do not provide complete protection against HPV. Discussing vaccination against HPV with your healthcare provider is also a good preventive measure for both you and your partner.


Conclusion
In summary, while 5FU cream is a valid treatment option, you may want to discuss the possibility of using Aldara or other treatments like podophyllin or interferon with your healthcare provider. Each treatment has its benefits and potential side effects, and the best choice will depend on your specific situation. Regular follow-ups and partner screening are crucial in managing genital warts and preventing further transmission. Always consult with your healthcare provider for personalized medical advice tailored to your condition.

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