Managing Abnormal Liver Function Tests: What Should You Do Next?

Q: Managing Abnormal Liver Function Tests: What Should You Do Next?

Hello Ms. <br>Chen： If you do not have hepatitis B or C, it is likely that fatty liver is the culprit (or drug-induced liver injury). <br>Since your liver enzyme levels are close to normal, there is no need for medication; you just need to consult a gastroenterologist to identify

How should abnormal liver function tests be managed?

Hello Dr.
Chen: My husband had a liver function test through a blood test six months ago, which showed SGOT/AST: 25 (the report indicates normal values are 12-33), SGPT/ALT: 38 (the report indicates normal values are 5-35), and surface antigen at 0.35 (-).
The laboratory personnel mentioned that it indicates liver inflammation.
Given the current situation, what would be the best course of action? My husband leads a normal lifestyle, does not smoke or drink, and has a regular sleep schedule.
The laboratory personnel suggested monitoring with another blood test.
Should we consider going to the hospital for a consultation for more safety? Thank you.

Miss Chen, 40~49 year old female. Ask Date: 2006/08/03

Dr. Chen Shidian reply Gastroenterology and Hepatology

Hello Ms.
Chen: If you do not have hepatitis B or C, it is likely that fatty liver is the culprit (or drug-induced liver injury).
Since your liver enzyme levels are close to normal, there is no need for medication; you just need to consult a gastroenterologist to identify the cause and monitor your condition.
Changhua Hospital cares about your health.
Sincerely, Chen Shidian.

Reply Date: 2006/08/03

More Info

Managing abnormal liver function tests can be a source of concern, especially when the results indicate potential liver inflammation or damage. In your husband's case, the SGOT (AST) and SGPT (ALT) levels are slightly elevated, which suggests that there may be some degree of liver stress or inflammation. However, it is important to interpret these results in the context of his overall health, lifestyle, and any symptoms he may be experiencing.

Understanding the Results
1. SGOT/AST and SGPT/ALT Levels:
- AST and ALT are enzymes found in the liver. Elevated levels can indicate liver inflammation or damage, but they are not specific to liver disease. Other conditions, such as muscle injury or heart disease, can also elevate these enzymes.

- In your husband's case, with AST at 25 (normal range 12-33) and ALT at 38 (normal range 5-35), the ALT is slightly above the normal range, indicating mild liver stress.

2. Surface Antigen:
- The surface antigen result of 0.35 indicates that he is negative for Hepatitis B, which is a positive sign as it rules out one of the common viral causes of liver inflammation.

Next Steps
1. Follow-Up Testing:
- It is advisable to follow up with additional blood tests to monitor liver function over time. This may include repeating the liver function tests in a few weeks to see if the enzyme levels return to normal or continue to rise.

- Additional tests may include viral hepatitis panels, autoimmune markers, and possibly imaging studies like an ultrasound to assess the liver's structure.

2. Lifestyle Considerations:
- Since your husband does not smoke or drink alcohol and maintains a regular sleep schedule, these are positive factors that can help protect liver health.
- Encourage a balanced diet rich in fruits, vegetables, whole grains, and lean proteins while avoiding processed foods and excessive fats, which can contribute to liver stress.

3. Consultation with a Specialist:
- Given the slight elevation in liver enzymes, it may be prudent to consult a gastroenterologist or hepatologist. They can provide a more comprehensive evaluation and determine if further investigation is necessary.

- A specialist may recommend additional tests such as a liver biopsy or FibroScan if there are concerns about chronic liver disease or fibrosis.

4. Monitoring Symptoms:
- Keep an eye on any symptoms that may arise, such as jaundice (yellowing of the skin or eyes), abdominal pain, fatigue, or changes in appetite. If any of these symptoms occur, seek medical attention promptly.

5. Regular Check-Ups:
- Regular follow-ups with healthcare providers are essential for monitoring liver health, especially if there are any changes in lifestyle or if new symptoms develop.

Conclusion
In summary, while your husband's liver function tests show a mild elevation in ALT, the overall picture is not alarming, especially considering his healthy lifestyle. However, it is wise to follow up with repeat testing and possibly consult a specialist to ensure that there are no underlying issues that need to be addressed. Regular monitoring and a healthy lifestyle will be key in managing his liver health moving forward.

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