Managing Severe Menstrual Pain: Insights on CA-125 and Endometriosis - Obstetrics and Gynecology

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CA-125: 139


Hello, I am 30 years old and have been experiencing menstrual pain for the past year and a half, which has progressively worsened and lasts throughout my entire menstrual period.
The pain is located in the lower right abdomen (around the appendix area), and during painful episodes, there is an increase in menstrual flow with some small blood clots.
The pain feels like continuous contractions of the uterus.
My doctor has performed several ultrasounds with no abnormalities found, and my CA-125 level was 139.
The doctor suspects I may have endometriosis and suggested hormonal treatment or surgical nerve removal, as well as traditional Chinese medicine.
However, my symptoms have not improved, and now I experience severe pain even outside of my menstrual period, which also affects my lower back.
This pain keeps recurring, and I am unsure how to proceed.
I am currently not in Taiwan; do I need to return urgently for treatment? Please help me!

Catheline, 30~39 year old female. Ask Date: 2006/08/11

Dr. Li Guanghan reply Obstetrics and Gynecology


Hello: Endometriosis can be treated with medication or surgery.
Many patients in our department have had quite good treatment outcomes.
You are welcome to visit us at the Department of Obstetrics and Gynecology, Hsinchu City Hospital.

Reply Date: 2006/08/11

More Info


Managing severe menstrual pain, especially when associated with conditions like endometriosis, can be quite challenging. Your symptoms, including the severe pain in the right lower abdomen, increased menstrual bleeding with clots, and the sensation of the uterus contracting, are indeed concerning and suggestive of endometriosis. The CA-125 level of 139 is elevated, which can be indicative of endometriosis or other pelvic conditions, although it's important to note that CA-125 is not exclusively specific to endometriosis and can be elevated in other conditions as well.


Understanding CA-125 and Endometriosis
CA-125 is a protein that is often elevated in women with endometriosis, ovarian cancer, and other pelvic inflammatory diseases. While it can be a useful marker in monitoring certain conditions, it is not definitive for diagnosing endometriosis. The elevated CA-125 levels you have experienced may warrant further investigation, especially given your ongoing symptoms.


Treatment Options
1. Hormonal Therapy: Hormonal treatments are often the first line of defense against endometriosis-related pain. These can include birth control pills, progestins, or GnRH agonists, which help to suppress the menstrual cycle and reduce or eliminate menstruation, thereby alleviating pain. If you have already tried hormonal treatments without success, it may be worth discussing alternative options with your healthcare provider.

2. Pain Management: Nonsteroidal anti-inflammatory drugs (NSAIDs) can help manage pain, but if they are not effective, your doctor might consider prescribing stronger pain medications or alternative therapies.

3. Surgical Options: If hormonal treatments and pain management strategies do not provide relief, surgical intervention may be necessary. This could involve laparoscopic surgery to remove endometrial tissue or adhesions. In some cases, a hysterectomy may be considered, especially if you are not planning to conceive in the future.

4. Alternative Therapies: While you mentioned seeking traditional Chinese medicine (TCM) treatment, it is essential to ensure that any alternative therapies are complementary to your primary treatment plan. Acupuncture, dietary changes, and herbal remedies may provide some relief, but they should be discussed with your healthcare provider to avoid any potential interactions with conventional treatments.


Next Steps
Given that your symptoms have persisted and worsened, it is crucial to seek further evaluation. If you are currently outside of Taiwan, consider finding a local gynecologist or specialist who can perform a thorough evaluation, including imaging studies and possibly a laparoscopy if indicated. If you feel that your current management is inadequate, returning to Taiwan for a more comprehensive evaluation may be warranted, especially if you have access to specialists who are experienced in managing endometriosis.


Conclusion
In summary, managing severe menstrual pain associated with suspected endometriosis requires a multifaceted approach. It is essential to work closely with your healthcare provider to explore all available treatment options, including hormonal therapies, pain management strategies, and possibly surgical interventions. If your symptoms continue to interfere with your quality of life, do not hesitate to seek further medical advice, whether locally or upon your return to Taiwan. Your health and well-being are paramount, and effective management of your symptoms is achievable with the right support and treatment plan.

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