Is It Medication or True Erectile Dysfunction? the Effects - Urology

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Is it due to medication or is it really erectile dysfunction? Continued 2?


Hello Doctor: I am the one who asked last time (Is it due to medication or true erectile dysfunction?), and here is the link: https://adoctor.tw/article/44977.
I have been taking Tofranil (25mg), Panadol (500mg) (Panamax), and Alinamin-F (50mg) for pain near my bladder for only three days.
In fact, I have been continuously taking Detrusitol SR (4mg) since last month, and everything has been normal during DIY activities.
However, since I started taking Tofranil (25mg), Panadol (500mg) (Panamax), and Alinamin-F (50mg), I have experienced erectile dysfunction and premature ejaculation.
I recall that three years ago, I also took Tofranil (25mg) for overactive bladder and experienced similar issues, so I hope this is temporary.
How long does it take for the effects of Tofranil (25mg) to wear off? Is it possible that Tofranil (25mg) has side effects for me, or is it true erectile dysfunction?

Xiao Xiao, 20~29 year old female. Ask Date: 2006/12/25

Dr. Xu Weikai reply Urology


Hello, generally speaking, Tofranil is metabolized quickly, and it usually takes about 3-5 days to return to baseline.
Erectile dysfunction caused by the medication typically resolves quickly after discontinuation.
However, some individuals may experience psychological barriers due to the erectile dysfunction during that period, which can lead to a persistent occurrence of erectile dysfunction.
This is a response from Dr.
Hsu Wei-Kai, Director of Urology at Taitung Hospital, Department of Health, Executive Yuan.

Reply Date: 2006/12/25

More Info


Erectile dysfunction (ED) can be a complex issue influenced by a variety of factors, including psychological, physiological, and medication-related causes. In your case, you are taking several medications, including Tofranil (amitriptyline), Panadol (paracetamol), and Alinamin-F, which may have contributed to your recent experiences with erectile dysfunction and premature ejaculation.

Tofranil, an antidepressant belonging to the tricyclic class, is often prescribed for depression and certain types of chronic pain, including bladder-related issues. However, one of the known side effects of Tofranil is sexual dysfunction, which can manifest as erectile dysfunction, decreased libido, or premature ejaculation. This side effect is not uncommon and can occur in both men and women. The mechanism behind this involves the drug's action on neurotransmitters in the brain, particularly serotonin and norepinephrine, which can affect sexual arousal and performance.

Panadol, which contains paracetamol, is generally considered safe and is not typically associated with sexual dysfunction. Alinamin-F, a combination of vitamins, is also unlikely to contribute to ED. However, the combination of medications you are taking could potentially lead to interactions that exacerbate side effects, including those related to sexual function.

The timeline for the resolution of side effects after discontinuing a medication like Tofranil can vary. Generally, the half-life of amitriptyline is about 10 to 50 hours, meaning it can take several days for the drug to be eliminated from your system. However, the duration of sexual side effects may persist beyond the drug's elimination, as the body may take time to readjust to the absence of the medication. It is not unusual for sexual function to return to baseline levels within a few weeks after stopping the medication, but this can vary significantly from person to person.

It is also important to consider psychological factors that may be contributing to your experience of erectile dysfunction. Anxiety about sexual performance, particularly if you have experienced ED in the past, can create a cycle of anxiety that further exacerbates the problem. Stress and psychological distress can significantly impact sexual function, and addressing these issues through counseling or therapy may be beneficial.

If you are concerned about the possibility of persistent erectile dysfunction or if it continues after the medication has cleared from your system, it is advisable to consult with a healthcare professional. They can help determine whether the issue is primarily medication-related or if there are other underlying causes that need to be addressed. Additionally, they may suggest alternative treatments or medications that have a lower risk of sexual side effects.

In summary, while it is possible that Tofranil is contributing to your erectile dysfunction and premature ejaculation, it is also essential to consider the psychological aspects and the potential for temporary side effects. Monitoring your symptoms after discontinuing the medication and seeking professional guidance will be crucial in determining the best course of action for your sexual health.

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