Alcohol-Like Effects from Long-Term Psychiatric Medications - Pharmacology

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The medication may cause a feeling of mild intoxication?


Hello, pharmacist.
I have been using psychiatric medications for over two years, but recently I have been experiencing a sensation similar to being slightly intoxicated after taking the medication.
I also notice that my perception of sound changes; for instance, when I talk, my voice seems to get louder, or when others speak, their voices seem to get quieter.
These feelings only occur after taking sedatives and sleeping pills, not at other times.
Is this normal? Additionally, I have been feeling a sense of unease lately.
What should I do?

Xun, 20~29 year old female. Ask Date: 2007/08/28

Dr. Hou Fangmin reply Pharmacology


Hello: When taking psychiatric medications that have antihistaminic or sedative effects, patients may experience symptoms such as slowed thinking and drowsiness due to excessive sedation, or side effects like behavioral rigidity.
As for the sensation you described that feels similar to being intoxicated, it may be a result of the sedative effects, making you feel as if you are under the influence of alcohol.
The feeling of nausea could be a side effect of the medication.
You may consider taking an antacid or a medication to alleviate side effects (such as Adan) to improve your symptoms, or consult with your attending physician.
Finally, I wish you good health.
Thank you for your valuable feedback.

Reply Date: 2007/08/28

More Info


Long-term use of psychiatric medications can lead to a variety of effects, some of which may mimic the sensations associated with alcohol consumption. The feelings of mild intoxication, such as a sense of euphoria, altered perception of sound, or a feeling of relaxation, can be attributed to the pharmacological effects of the medications you are taking.
Many psychiatric medications, particularly sedatives and anxiolytics, can produce effects similar to those of alcohol. For instance, medications like benzodiazepines (e.g., Alprazolam, which is often prescribed for anxiety) and certain sleep aids (like Zolpidem) work by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA). This neurotransmitter has inhibitory effects on the nervous system, leading to feelings of calmness and sedation, much like the effects of alcohol.
The sensations you describe, such as feeling slightly tipsy or experiencing changes in auditory perception, may be side effects of the medications you are taking. These effects can be more pronounced when the medications are taken in combination or when the dosage is adjusted. It’s also important to consider that individual responses to medications can vary widely; some people may experience these sensations more intensely than others.

Regarding your concerns about feeling "off" or experiencing a sense of unease (which you referred to as "ㄜ心感"), this could be a sign of several factors at play. It may be related to the medications themselves, potential interactions between different medications, or even the underlying condition being treated. For example, some psychiatric medications can lead to side effects such as dizziness, lightheadedness, or changes in mood, which could contribute to feelings of discomfort.

If you are experiencing these sensations consistently after taking your medications, it is crucial to discuss this with your prescribing physician or psychiatrist. They can evaluate your current medication regimen, assess for any potential interactions, and determine if adjustments are necessary. It is essential not to make any changes to your medication without professional guidance, as this could lead to withdrawal symptoms or a resurgence of your underlying condition.

In addition to medication management, consider discussing non-pharmacological approaches to managing your symptoms. Cognitive-behavioral therapy (CBT), mindfulness practices, and lifestyle modifications (such as regular exercise, a balanced diet, and good sleep hygiene) can complement your treatment and may help alleviate some of the discomfort you are experiencing.

In summary, while the sensations you are experiencing may be related to your long-term use of psychiatric medications, it is essential to consult with your healthcare provider to ensure your treatment plan is safe and effective. They can help you navigate these side effects and make any necessary adjustments to improve your overall well-being.

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