Septic Shock: A Family's Struggle with Cancer and Complications - Surgery

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Could you please help me, doctor?


Dear Dr.
Ke,
I hope you remember me; it has been a while since I last asked a question.
During this time, my father's bowel obstruction issue has not been resolved, and his condition has been deteriorating.
On September 9 of this year, my father suddenly experienced chills, shivering, and a high fever at home.
He was then urgently taken to the emergency room at Kaohsiung Medical University.
After observation, the doctors informed us that my father was in "septic shock." After researching online, I realized the severity of septic shock, as his blood pressure was unstable and low.
The doctors did their best to stabilize him, but his blood pressure remained around 100 systolic.

The doctors have informed us about my father's condition; he has rectal cancer, classified as T3N2M0.
They said that the cancer cells have obstructed his entire intestine (it has metastasized).
A few days ago, my father complained of severe abdominal pain, and after an ultrasound examination, the doctors found fluid accumulation in his abdomen and decided to perform a paracentesis.
They drained 500cc of fluid, but afterward, my father's blood pressure dropped further, and he began to experience shortness of breath, putting him in a more critical situation.
He is now in the intensive care unit receiving treatment, including vasopressors, inotropes, oxygen therapy, and due to his low urine output, the doctors mentioned that he may need dialysis.
Seeing my father connected to various tubes and IV lines is incredibly distressing and heartbreaking.
I feel lost and do not know what to do.
How could such a virulent bacterial infection enter his bloodstream? I hope he can overcome this challenge of septic shock.

Yifang, 20~29 year old female. Ask Date: 2007/10/03

Dr. Ke Fangxu reply Surgery


I am very sorry to hear about your father's condition.
However, if the cancer cells have already metastasized, the tumor staging should be T3N2M1-2.
The cause of septic shock may be related to bowel obstruction, as bowel obstruction can lead to increased intestinal pressure, causing bacteria to migrate from the intestines into the abdominal cavity, resulting in septic shock.
However, if the symptoms are due to cachexia caused by the spread of cancer cells, this could also explain the condition.
If your father's condition has progressed to this point and cancer cells have indeed metastasized throughout the intestines causing an obstruction, it can be considered terminal.
Although this may sound harsh, you may need to start considering the possibility of palliative care, which could help alleviate some of your father's suffering.

Reply Date: 2007/10/03

More Info


Septic shock is a critical condition that arises when the body responds to an infection with a severe inflammatory reaction, leading to dangerously low blood pressure and organ dysfunction. In the context of your father's situation, it is particularly concerning given his history of rectal cancer and the complications arising from bowel obstruction.
When cancer spreads, it can cause various complications, including bowel obstruction, which can lead to a buildup of bacteria in the intestines. This can result in bacteria entering the bloodstream, causing sepsis, and ultimately leading to septic shock. The fact that your father has been diagnosed with T3N2M0 rectal cancer indicates that the cancer has spread to nearby lymph nodes but not to distant sites, which complicates his treatment and prognosis.

The symptoms your father experienced—chills, shaking, and high fever—are classic signs of an infection that could lead to septic shock. The medical team’s decision to admit him to the intensive care unit (ICU) and administer vasopressors, inotropes, and oxygen therapy is standard practice in managing septic shock. These interventions are aimed at stabilizing blood pressure, improving heart function, and ensuring adequate oxygenation of tissues.

The presence of ascites (fluid accumulation in the abdomen) and the need for dialysis indicate that your father's condition is quite severe. Ascites can occur due to various reasons, including liver dysfunction or cancer-related complications. The fact that he is experiencing low urine output suggests that his kidneys may be struggling to function properly, which is another common complication in septic shock.

As for the question of how such a severe bacterial infection could occur, it is important to understand that in patients with cancer, especially those undergoing treatments that may compromise the immune system, the risk of infections increases significantly. The cancer itself can also disrupt normal bodily functions, making it easier for infections to take hold.

In terms of treatment, the focus will be on addressing the underlying infection, which may involve antibiotics and possibly surgical intervention if there is an obstruction that needs to be resolved. The medical team will also closely monitor your father's vital signs and organ function, adjusting treatments as necessary.

It is understandable to feel overwhelmed and heartbroken seeing a loved one in such a critical state. It is important to communicate openly with the healthcare team about your father's condition and treatment options. They can provide you with the most accurate information regarding his prognosis and the steps being taken to manage his care.

While the situation is undoubtedly dire, it is essential to remain hopeful and supportive. Engage with the medical staff, ask questions, and seek clarity on any uncertainties you may have. They are there to help you navigate this challenging time. Additionally, consider seeking support for yourself and your family, as dealing with a loved one's severe illness can take a significant emotional toll. Support groups or counseling can provide a safe space to express your feelings and receive guidance during this difficult journey.

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