Low Lymphocytes and High Eosinophils: What It Means for Your Health - Family Medicine

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Low lymphocyte count and high eosinophil count?


Hello Dr.
Wang, I have two questions I would like to ask you.
I had a health check-up at my company in mid-October, and two of my results were abnormal.

1.
My lymphocyte count is low.
The normal range is 20-56%, and my result is 19.6%.

2.
My eosinophil count is high.
The normal range is 0-5%, and my result is 9.9%.

Additionally, I have been experiencing stomach pain for a while and underwent an endoscopy.
The doctor mentioned that there is mild erosion and slight bleeding at the pylorus of my stomach.
He said that taking medication for a while would help, but it has been almost two months, and my symptoms fluctuate; I still often have stomach pain, especially when fasting.

Could you please advise if these two abnormal results are related to my symptoms? What do these two abnormalities indicate? Should I undergo any further tests? Thank you for your assistance.

Meimei, 30~39 year old female. Ask Date: 2007/11/08

Dr. Wang Zhengzhong reply Family Medicine


Hello, dear community member:
Regarding your questions: 1.
Your lymphocyte count is low.
The normal range is 20-56%, and your value is 19.6%.
This is slightly below normal but not significantly abnormal.
2.
Your eosinophil count is elevated.
The normal range is 0-5%, and your value is 9.9%.
Additionally, you have a gastric condition.
To further investigate this, a pathological biopsy of the stomach or intestines may be necessary, or stool tests or blood tests, including IgE levels, could provide more information.
However, the information you provided is still incomplete.
Please consult with a family medicine or gastroenterology specialist so that we can assist you better.

Wishing you health and happiness,
Wang Zhengzhong, Department of Geriatrics, Hsinchu Hospital

Reply Date: 2007/11/08

More Info


Hello! Thank you for your questions regarding your recent health check-up results, specifically concerning your low lymphocyte count and elevated eosinophil levels. Let's break down what these findings might indicate and how they could relate to your ongoing gastrointestinal symptoms.


Understanding Your Blood Test Results
1. Low Lymphocyte Count (19.6%):
- Lymphocytes are a type of white blood cell that plays a crucial role in your immune system, particularly in fighting viral infections and regulating immune responses. A normal range for lymphocytes is typically between 20-56%. Your count being slightly below this range may suggest a few possibilities:
- Acute or Chronic Infection: Sometimes, during an infection, lymphocyte levels can drop as the body directs resources to fight off the pathogen.

- Stress Response: Physical or emotional stress can temporarily lower lymphocyte counts.

- Autoimmune Disorders: Conditions like lupus or rheumatoid arthritis can affect lymphocyte levels.

- Nutritional Deficiencies: Deficiencies in vitamins and minerals, particularly vitamin B12 and folate, can lead to lower lymphocyte counts.

2. High Eosinophil Count (9.9%):
- Eosinophils are another type of white blood cell that primarily responds to allergic reactions and parasitic infections. Normal levels are typically between 0-5%. An elevated eosinophil count can indicate:
- Allergic Reactions: Conditions such as asthma, hay fever, or food allergies can cause eosinophilia.

- Parasitic Infections: Certain infections, particularly those caused by parasites, can lead to increased eosinophil levels.

- Autoimmune Diseases: Some autoimmune conditions can also cause elevated eosinophils.

- Certain Cancers: Rarely, some cancers can lead to increased eosinophil production.


Possible Connections to Your Gastrointestinal Symptoms
Your ongoing gastric symptoms, including pain and the findings of mild erosion and bleeding in the pylorus, could potentially be related to your blood test results, although they are not directly indicative of each other. Here are some considerations:
- Eosinophilic Esophagitis: This is a condition characterized by eosinophilic infiltration in the esophagus, often related to food allergies. If your eosinophil count is high, it might be worth discussing this possibility with your doctor.

- Gastritis or Peptic Ulcer Disease: The erosion and bleeding in your stomach could be due to gastritis or ulcers, which can be exacerbated by stress or certain medications (like NSAIDs). If your lymphocyte count is low due to stress or an underlying infection, this could potentially affect your stomach's healing process.

- Allergic Reactions: If you have food allergies contributing to your eosinophilia, they could also be causing gastrointestinal symptoms.


Next Steps
1. Follow-Up with Your Doctor: It’s essential to discuss these results with your healthcare provider, who can interpret them in the context of your overall health and symptoms. They may recommend further testing, such as:
- Allergy Testing: To determine if you have any food allergies contributing to your eosinophilia.

- Repeat Blood Tests: To monitor your lymphocyte and eosinophil levels over time.

- Endoscopy: If your gastric symptoms persist, further evaluation of your gastrointestinal tract may be warranted.

2. Monitor Symptoms: Keep a diary of your symptoms, noting when they occur, their severity, and any potential triggers. This information can be valuable for your healthcare provider.

3. Lifestyle and Dietary Adjustments: Consider discussing dietary changes with a nutritionist, especially if food allergies are suspected. Additionally, managing stress through relaxation techniques or counseling may help improve your lymphocyte count.

In conclusion, while your low lymphocyte and high eosinophil counts warrant further investigation, they may not directly correlate with your gastric symptoms. A comprehensive approach involving your healthcare provider will be crucial in addressing these concerns effectively. Thank you for reaching out, and I hope this information helps guide your next steps!

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