Effectiveness of Acyclovir vs. Diflucan for Treating Shingles

Q: Effectiveness of Acyclovir vs. Diflucan for Treating Shingles

Dear Q： Xyzal (levocetirizine dihydrochloride) 5mg is a third-generation antihistamine derived from the second-generation Zyrtec (cetirizine 10mg), which improves upon the sedation and dizziness side effects associated with the second generation. <br>The package insert states tha

Measles

Which of the two medications, Acyclovir or Valacyclovir, is more effective for herpes zoster? What are the side effects? Is topical hydrocortisone effective for herpes zoster? Can it be used in combination with these medications?

Q, 20~29 year old female. Ask Date: 2008/01/02

Dr. Zhang Zhibo reply Dermatology

Dear Q: Xyzal (levocetirizine dihydrochloride) 5mg is a third-generation antihistamine derived from the second-generation Zyrtec (cetirizine 10mg), which improves upon the sedation and dizziness side effects associated with the second generation.
The package insert states that clinical trials have shown no evidence that cetirizine (the isomer of levocetirizine) affects mental alertness or driving ability at recommended doses.
However, if one expects to drive, engage in hazardous activities, or operate machinery, the dosage should not exceed the recommended amount, which is 0.5 to 1 tablet.
It is not recommended for children under six years of age.
For patients with renal impairment, the dosing interval should be adjusted based on their renal function status.
For patients with liver impairment, no dosage adjustment is necessary.

Allegra (fexofenadine hydrochloride) 60mg/180mg is also a third-generation antihistamine, a metabolite of the second-generation terfenadine, without the arrhythmogenic side effects associated with terfenadine.
It similarly has a lower incidence of sedation side effects.
The dosing regimen includes 60mg twice daily or 180mg once daily, among others.
The effectiveness of antihistamines can vary from person to person, primarily depending on individual tolerance and convenience in choosing which one to use.
Side effects may include dizziness, headache, sedation, dry mouth, and urinary retention, among others.

Doxepin HCl 5% topical medication is also an antihistamine with properties of both first and second-generation antihistamines, making it suitable for treating urticaria.
All antihistamines of different types can be combined for treatment.

Reply Date: 2008/01/02

More Info

When it comes to treating shingles (herpes zoster), both Acyclovir and Diflucan (fluconazole) are medications that may be considered, but they serve different purposes and have different effectiveness profiles.

Acyclovir is an antiviral medication that is specifically indicated for the treatment of infections caused by certain types of viruses, including the varicella-zoster virus, which is responsible for shingles. Acyclovir works by inhibiting the replication of the virus, thereby reducing the severity and duration of the shingles outbreak. It is most effective when started within 72 hours of the onset of the rash. Common side effects of Acyclovir may include nausea, diarrhea, headache, dizziness, and in rare cases, renal toxicity, especially if hydration is not maintained during treatment.

On the other hand, Diflucan (fluconazole) is an antifungal medication primarily used to treat fungal infections. It is not indicated for viral infections like shingles and would not be effective in treating the condition. Therefore, it is not a suitable choice for shingles treatment.

Regarding the use of 普膚乳膏 (Puful Cream), which is often used for skin conditions, it may provide symptomatic relief for the skin irritation associated with shingles. However, it does not treat the underlying viral infection. If you are considering using Puful Cream in conjunction with Acyclovir, it is generally safe to do so, as topical treatments can help soothe the skin without interfering with the antiviral action of Acyclovir.

In summary, for treating shingles, Acyclovir is the appropriate medication, while Diflucan is not effective for this viral infection. If you are experiencing shingles, it is crucial to start antiviral treatment as soon as possible to minimize complications and promote faster healing. Always consult with your healthcare provider before starting any new medication or combining treatments to ensure safety and efficacy based on your specific health needs.

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