Timing Your Medications: Aspirin vs. Antacids Explained - Pharmacology

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Issues related to the concurrent use of Aspirin and antacids?


It is recommended to take Bokey (Aspirin) first and then wait at least one hour before taking the antacid (Gowell).
This is because taking aspirin on an empty stomach can enhance its absorption and effectiveness, while antacids can interfere with the absorption of certain medications, including aspirin, if taken together.
Therefore, taking aspirin first helps ensure that it is properly absorbed before the antacid is consumed.

Maria, 30~39 year old female. Ask Date: 2008/03/18

Dr. Zheng Yizhan reply Pharmacology


Hello Ms.
Maria: This is Pharmacist Zheng from the Municipal Hospital responding to your question.
You asked whether to take Bokey (Aspirin) or the antacid (Gowell) first, given that they should be taken one hour apart.
You should take Bokey (Aspirin) first and then wait one hour before taking the antacid (Gowell).
This is because Bokey is an enteric-coated capsule, and taking the antacid first may cause Bokey to dissolve in the stomach, irritating the gastric lining and leading to discomfort.

Additionally, you inquired about the reason for taking the antacid (Gowell).
It is typically used for gastrointestinal discomfort or issues such as gastrointestinal bleeding.
If there is a concern about gastrointestinal bleeding, the use of Bokey (salicylate) is not recommended.
If you have any unclear points or further questions, please consult the prescribing physician or the pharmacist who dispensed your medication for more clarification.

Sincerely, Pharmacist Zheng, Taitung Municipal Hospital, March 18, 2008.

Reply Date: 2008/03/18

More Info


When it comes to the timing of medications, particularly between aspirin (like Bokey) and antacids (like Gowell), it is essential to understand how these medications interact with each other and their respective mechanisms of action.

Aspirin is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used for pain relief, anti-inflammatory purposes, and as an antiplatelet agent to reduce the risk of heart attacks and strokes. On the other hand, antacids are used to neutralize stomach acid and relieve symptoms of heartburn, indigestion, and gastroesophageal reflux disease (GERD).

The recommendation to space these medications apart by at least one hour is primarily due to the potential for antacids to interfere with the absorption of aspirin. Antacids can alter the pH level in the stomach, which may affect how well aspirin is absorbed into the bloodstream. If taken together, the antacid could reduce the effectiveness of aspirin, leading to suboptimal therapeutic outcomes.

In terms of which medication to take first, it is generally advisable to take aspirin first, followed by the antacid after a one-hour interval. This approach allows for optimal absorption of aspirin without the interference of the antacid. By taking aspirin first, you ensure that it is absorbed effectively before the antacid alters the stomach environment.

Moreover, it is important to consider the specific indications for each medication. If you are taking aspirin for cardiovascular protection or pain relief, ensuring its effectiveness is crucial. Conversely, if you are experiencing gastrointestinal discomfort, the antacid will provide relief, but it should not compromise the efficacy of your aspirin therapy.

In summary, when taking Bokey (aspirin) and Gowell (antacid), it is best to take aspirin first and then wait at least one hour before taking the antacid. This timing helps maximize the effectiveness of both medications while minimizing any potential interactions. Always consult with your healthcare provider or pharmacist if you have specific concerns about your medication regimen, as they can provide personalized advice based on your health status and other medications you may be taking.

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