Favism: Blood Tests and Military Exemption Criteria - Internal Medicine

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Regarding the issue of Favism?


Hello, doctor! I would like to ask if testing for G6PD deficiency can be done with a regular blood test? Additionally, I have heard that patients with G6PD deficiency may be exempt from military service.
According to the current "Standards for Classification of Physical Condition" under item 92, hereditary anemia must be evaluated based on hemoglobin test results.
A hemoglobin level of 13 gm/dL or above is classified as active duty status, 11 to 12.9 gm/dL as alternative service status, and below 11 gm/dL as exempt from service.
What classification would a typical G6PD deficiency patient fall under, or does it vary for each individual?

Lai, 10~19 year old female. Ask Date: 2008/04/08

Dr. Yang Hongzhi reply Internal Medicine


Hello: Favism is caused by a deficiency of the enzyme G6PD.
Diagnosis can be made by testing the activity of G6PD through a blood sample.
Most individuals with this condition are asymptomatic, and hemolytic anemia occurs only after the ingestion of certain medications or foods.

Reply Date: 2008/04/08

More Info


Favism, or G6PD deficiency, is a genetic condition that affects the enzyme glucose-6-phosphate dehydrogenase (G6PD), which plays a crucial role in protecting red blood cells from oxidative damage. Individuals with this deficiency may experience hemolytic anemia when exposed to certain triggers, including fava beans, infections, or certain medications. Understanding how to diagnose this condition and its implications for military service is essential for those affected.

To diagnose G6PD deficiency, a simple blood test is typically performed. This test measures the level of G6PD enzyme activity in red blood cells. If the enzyme activity is low, it indicates a deficiency. In some cases, a hemoglobin electrophoresis test may also be conducted to evaluate the types of hemoglobin present and to rule out other forms of anemia. It's important to note that testing should ideally be done during a period when the individual is not experiencing hemolysis, as this can affect enzyme levels and lead to false results.

Regarding military exemption criteria, the regulations you mentioned are indeed relevant. In many countries, including Taiwan, individuals with hereditary conditions such as G6PD deficiency may be classified based on their hemoglobin levels. The criteria you provided indicate that:
- A hemoglobin level of 13 g/dL or higher qualifies for active military service.

- A level between 11 and 12.9 g/dL may qualify for alternative service.

- A level below 11 g/dL typically exempts an individual from military service.

For individuals with G6PD deficiency, their hemoglobin levels can fluctuate, especially if they experience hemolytic episodes. Therefore, the classification may vary depending on their current health status and hemoglobin levels at the time of assessment. It is crucial for individuals with this condition to maintain regular check-ups and monitor their hemoglobin levels, especially before any military evaluations.

In terms of military classification, it is essential to consult with a healthcare provider who understands the nuances of G6PD deficiency and its implications for military service. Each patient's situation can differ significantly based on their overall health, frequency of hemolytic episodes, and other underlying conditions. Therefore, a personalized assessment is necessary to determine the appropriate military classification.

In summary, to test for Favism, a blood test measuring G6PD enzyme activity is required. The implications for military service depend on the individual's hemoglobin levels, which can vary based on their health status. Regular monitoring and consultation with healthcare professionals are vital for managing G6PD deficiency and understanding its impact on military obligations.

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