Thyroid Disorders: Concerns for Nursing Mothers - Internal Medicine

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Thyroid-related disorders?


Hello Dr.
Yang, I have been diagnosed with hyperthyroidism for about fifteen years.
Ten years ago, I underwent radioactive iodine treatment twice, but there was no improvement.
Since then, I have been taking antithyroid medication (the doctor mentioned that I might need to take it for life).
Approximately ten years ago, I noticed white spots starting to appear on my fingers.
Initially, I didn't pay much attention, but they have been increasing in number.
In July 2006, I had blood tests done at the hospital, and the relevant results were Free T4: 0.47, T3: 102, TSH: 47.8, Microsomal Antibody: 1:2560, and Thyroglobulin Antibody: 1:640.
I have been consistently taking the antithyroid medication Polupi 50mg (currently taking half a tablet daily).
During my pregnancy two years ago, I was cautious not to stop the medication, and my baby’s newborn screening showed TSH: 1.0 at birth.
Now that my baby is eight months old, I am most concerned about breastfeeding.
I would like to ask: 1.
I cannot find any information online regarding the classification of Polupi and whether this type and dosage of medication could be transmitted through breast milk to my baby.
2.
Given the high levels of MA and TA in my blood, could these antibodies also be present in my breast milk? I am worried that my baby might be affected and develop white spots.
3.
Will thyroid-related antibodies (such as MA and TA) potentially decrease with age? Should I have regular blood tests to monitor these levels? 4.
If I have not been able to stop medication even after receiving radioactive iodine treatment, does this mean I will need to continue taking medication for life? Thank you!

mimi, 40~49 year old female. Ask Date: 2008/05/04

Dr. Yang Hongzhi reply Internal Medicine


Hello: Polupi can still be present in breast milk, but the concentration is very low, and the dosage taken is also low, so the actual impact may be minimal.
Vitiligo is related to autoimmune conditions, but it is not directly associated with thyroid-related antibodies, so there are no concerns regarding breastfeeding in this regard.
The levels of antibodies have some correlation with thyroid function, but it is not absolute.
Thyroid function should definitely be monitored, but there is no absolute necessity to track antibodies! The blood test from July 1995 indicated hypothyroidism; whether medication is needed should be discussed with a physician!

Reply Date: 2008/05/04

More Info


When caring for a mother with thyroid disorders, particularly hyperthyroidism, there are several important considerations to keep in mind, especially if she is nursing. Your concerns about the medication, its effects on breast milk, and the potential impact on your baby are valid and warrant careful attention.

1. Medication and Breastfeeding: The medication you mentioned, Polupi (which contains methimazole), is commonly prescribed for hyperthyroidism. Generally, methimazole is considered safe for breastfeeding mothers. Studies have shown that only a small amount of this medication passes into breast milk, and the levels are typically low enough that they are unlikely to cause harm to a nursing infant. However, it is crucial to discuss this with your healthcare provider to ensure that the benefits of continuing the medication outweigh any potential risks.

2. Antibodies in Breast Milk: Regarding your concern about the presence of microsomal and thyroglobulin antibodies in breast milk, it is important to note that while these antibodies can be present in the bloodstream, their transfer to breast milk is not well understood. The risk of your baby developing conditions like vitiligo (white patches on the skin) due to maternal antibodies is considered low, but it is essential to monitor your child’s health and skin condition. If you notice any unusual changes, consult a pediatrician.

3. Monitoring Thyroid Antibodies: Thyroid-related antibodies, such as microsomal and thyroglobulin antibodies, can fluctuate over time. While some individuals may see a decrease in these antibodies as they age, others may not. Regular monitoring of thyroid function and antibody levels is advisable, especially since you have a history of thyroid disease. Your healthcare provider can recommend how often you should have blood tests to track your thyroid levels and antibodies.

4. Long-term Medication Use: The need for lifelong medication in cases of hyperthyroidism can vary. Some individuals may achieve remission and can discontinue medication, while others may require long-term treatment. Since you have a history of persistent hyperthyroidism despite previous treatments, it is likely that ongoing medication will be necessary. Regular follow-ups with your endocrinologist will help determine the best course of action for your specific situation.

5. Impact on Nursing: It is essential to maintain a stable thyroid function while breastfeeding, as both hyperthyroidism and hypothyroidism can affect milk production and overall maternal health. If you experience any symptoms of thyroid imbalance (such as fatigue, weight changes, or mood swings), it is crucial to seek medical advice promptly.

6. Nutritional Considerations: As a nursing mother, maintaining a balanced diet rich in essential nutrients is vital for both your health and your baby's development. Ensure you are getting adequate iodine, as it is crucial for thyroid function and fetal development. However, avoid excessive iodine intake, as it can exacerbate hyperthyroidism.

In conclusion, managing hyperthyroidism while nursing requires careful coordination with healthcare providers. Regular monitoring of thyroid levels, adherence to prescribed medications, and a focus on nutrition will help ensure both your health and that of your baby. Always feel free to reach out to your healthcare team with any concerns or questions you may have as you navigate this journey.

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