Out-of-pocket medication
Dear Dr.
Wu,
Currently, my white blood cell count often drops to around 1000.
Despite receiving white blood cell growth factors, I frequently experience fevers and have had to visit the emergency room.
After the fever subsided, I continued to receive antibiotics for several days and took penicillin for a week.
I really can't continue with chemotherapy; the doctor decided to postpone the third cycle by a week.
Due to the low white blood cell count, the dosage was reduced during the second treatment, and I am very concerned that this will affect the treatment efficacy.
So far, I have completed two cycles of chemotherapy (one week of European purple and Jianze, followed by Jianze every other week) and have undergone two rounds of CT scans, which showed no cancer cells.
I plan to complete the entire treatment course before undergoing a PET scan.
My HER2 status is confirmed positive, and I am considering self-paying for Avastin before Lapatinib becomes available, and I will apply for cancer treatment coverage under the National Health Insurance.
I have the following questions:
1.
What are the potential effects on the body from excessive antibiotic use?
2.
Can I trust the CT scan results? Are they more reliable than ultrasound? (I just had an ultrasound and found something myself, so I am not very confident in the ultrasound results.) Is it necessary to have another PET scan?
3.
Which self-paid medication should I use first? If I use them all, will I run out of options if my condition worsens in the future?
4.
If there are currently no cancer cells, is it still necessary to use self-paid medications? Would it be a waste, or do they provide additional benefits?
5.
Will continuously reducing the dosage affect the treatment efficacy?
Thank you for taking the time to answer my questions despite your busy schedule.
len, 40~49 year old female. Ask Date: 2008/05/21
Dr. Wu Jingtang reply Breast and Thyroid
Dear Miss Len,
First of all, congratulations on finding the appropriate medication and currently having no residual tumors! Keep up the good work!
1.
What are the effects of excessive antibiotic use on the body? --> If their use is necessary, the benefits outweigh the risks, so this can be disregarded!
2.
Can we trust the results of the CT scan? Is it more reliable than ultrasound? --> CT scans are generally more reliable than ultrasounds! Of course, after completing a certain number of chemotherapy sessions, it is necessary to perform another PET scan.
3.
Will continuously reducing the dosage affect the treatment efficacy? --> Adjusting the dosage based on response or side effects is essential! You can discuss with your physician whether to complete a few more cycles to reach the originally set dosage (but at a lower or reduced dosage each time).
4.
If there are currently no cancer cells, is it still necessary to use self-funded medications? Would it be a waste? Is there an additive effect? Which self-funded medication should be used first? If all are used, will we run out of options if the condition worsens later? --> If the current medication is effective, it should continue to be used.
In many countries, it is recommended to keep using it until there is a recurrence before changing medications! You can discuss with your physician whether to take a break after one treatment cycle before starting another, as there is no definitive conclusion on this yet! Especially since self-funded medications are very expensive! Whether we "run out of bullets" depends on the speed of new drug development! If finances are not an issue, "Avastin" should have a certain level of effectiveness!
Wishing you success in your cancer treatment!
Sincerely,
Dr.
Wu Ching-Tang
Attending Surgeon, Taoyuan Hospital, Ministry of Health and Welfare
Reply Date: 2008/05/21
More Info
Navigating the complexities of breast cancer treatment, especially when dealing with thyroid issues and the potential need for self-paid medications, can be quite challenging. Your concerns about the impact of antibiotics, imaging reliability, and the strategic use of medications are valid and deserve careful consideration.
1. Impact of Excessive Antibiotic Use: Overuse of antibiotics can lead to several adverse effects. One of the most significant concerns is the development of antibiotic resistance, which can make future infections harder to treat. Additionally, antibiotics can disrupt the normal flora of the gut, leading to gastrointestinal issues such as diarrhea or Clostridium difficile infection. They can also affect the immune system, potentially leading to increased susceptibility to infections. Given your low white blood cell count, it's crucial to discuss with your healthcare provider the necessity and duration of antibiotic therapy to minimize these risks.
2. Reliability of Imaging Results: Imaging studies such as CT scans and ultrasounds serve different purposes and have varying degrees of reliability. CT scans are generally more sensitive and can provide a more comprehensive view of the body's internal structures compared to ultrasounds. However, the reliability of any imaging study can be influenced by several factors, including the skill of the technician and the specific characteristics of the tumor. If you have concerns about the accuracy of your ultrasound results, discussing the need for a PET scan with your oncologist could be beneficial. A PET scan can provide additional information about metabolic activity in tissues, which may help clarify the status of any suspicious areas.
3. Choosing Self-Paid Medications: When considering self-paid medications like Avastin or Lapatinib, it's essential to weigh the potential benefits against the costs and your current health status. Starting with a medication that has a strong evidence base for your specific cancer type and stage is advisable. Using multiple medications simultaneously can be tempting, but it’s crucial to avoid "using all your bullets at once." This strategy could limit future treatment options if the cancer were to recur. Discussing a phased approach with your oncologist, where you start with one medication and monitor its effectiveness before adding others, may be more prudent.
4. Need for Self-Paid Medications if No Cancer Cells are Detected: If imaging results indicate no cancer cells, the necessity of self-paid medications should be carefully evaluated. While some medications may provide a preventative benefit, they can also carry risks and costs. It’s essential to have a thorough discussion with your oncologist about the potential for recurrence and whether the benefits of continuing treatment with self-paid medications outweigh the risks and costs.
5. Impact of Dose Reduction on Efficacy: Dose reductions can indeed affect the efficacy of cancer treatments. Lower doses may not provide the same therapeutic effect as full doses, potentially leading to suboptimal outcomes. However, dose adjustments are sometimes necessary to manage side effects and maintain the patient's overall health. It’s crucial to have ongoing discussions with your healthcare team about the best approach to balance efficacy and tolerability.
In conclusion, navigating breast cancer treatment alongside thyroid issues requires a collaborative approach with your healthcare team. Regular communication about your concerns, treatment goals, and any side effects you experience is vital. Your treatment plan should be tailored to your specific needs, considering both the current status of your cancer and your overall health. Always feel empowered to ask questions and seek clarity on your treatment options, as this is an essential part of managing your health journey.
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