CIDP: Treatment Options and Recovery Expectations - Neurology

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Chronic Inflammatory Dem


Hello Dr.
Lin, my friend (27 years old) sought medical attention a year ago due to muscle paralysis and weakness, and was diagnosed with Guillain-Barré Syndrome (GBS).
He received one infusion of IVIg, which provided slight improvement, but after half a month, the paralysis sensation worsened again.
He has been undergoing daily rehabilitation but has not seen significant improvement.
About six months ago, the doctor suggested that he likely has Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).
Currently, his treatment consists of daily medication and rehabilitation, and he only feels a slight improvement.

I would like to ask, how long does it typically take for CIDP to potentially heal? Is complete recovery possible? What medications do general CIDP patients usually take? My friend is currently only taking steroids; is this the correct treatment approach? If he recovers in the future, will he still need to continue taking them? I am concerned about the side effects of steroids, especially since he has not improved.
Would receiving IVIg infusions again be beneficial? Additionally, I have heard that reishi mushrooms may be helpful for immune system issues; is this true?
I apologize for asking so many questions, Dr.
Lin, but I am very worried about my friend’s ongoing condition and hope you can help.
Thank you, and I look forward to your response.

Han, 20~29 year old female. Ask Date: 2008/07/21

Dr. Lin Zijing reply Neurology


Hello: The course of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is slower and more prone to relapse compared to Acute Inflammatory Demyelinating Polyneuropathy (AIDP, also known as Guillain-Barré Syndrome).
Some patients experience intermittent episodes, while others have a gradual progression of weakness.
The symptoms primarily include symmetrical weakness and sensory disturbances in the upper and lower limbs.
Over time, muscle atrophy is common.
Statistics show that patients with intermittent episodes tend to have a better prognosis, but the recovery time is determined by the extent of nerve damage.
This condition is a treatable form of polyneuropathy.
Treatment options include rehabilitation exercises, pharmacological therapy, and plasmapheresis or intravenous immunoglobulin (IVIg) therapy.
The primary medication choice is corticosteroids, and if the response is inadequate, other immunosuppressants may be added.
Once strength gradually improves, the use of medications can be tapered off slowly, while plasmapheresis or IVIg can be used again if the condition worsens.
As for the efficacy of Lingzhi (Reishi mushroom), that remains uncertain.

Reply Date: 2008/07/21

More Info


Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a neurological disorder characterized by progressive weakness and impaired sensory function due to damage to the myelin sheath of peripheral nerves. Understanding the treatment options and recovery expectations for CIDP is crucial for patients and their families, especially when dealing with the complexities of this condition.

Firstly, it is important to note that CIDP is a chronic condition, and the recovery process can vary significantly from one individual to another. Some patients may experience substantial improvement, while others may have persistent symptoms. The timeline for recovery can be unpredictable; some patients may begin to see improvements within weeks to months after starting treatment, while others may take longer. In many cases, ongoing treatment and rehabilitation are necessary to manage symptoms and improve quality of life.

The primary treatment options for CIDP include corticosteroids, intravenous immunoglobulin (IVIg), and plasmapheresis. Corticosteroids, such as prednisone, are commonly prescribed to reduce inflammation and suppress the immune response. While they can be effective, long-term use can lead to side effects, including weight gain, osteoporosis, and increased risk of infections. Therefore, it is essential to monitor the patient closely and adjust the treatment plan as needed.

Intravenous immunoglobulin (IVIg) is another effective treatment for CIDP. It works by modulating the immune system and is often used when patients do not respond adequately to steroids. Some patients may benefit from a combination of treatments, including both steroids and IVIg, depending on their specific symptoms and response to therapy. If your friend has not seen significant improvement with steroids alone, discussing the possibility of resuming IVIg with their healthcare provider may be a worthwhile consideration.

Plasmapheresis, a procedure that filters the blood to remove harmful antibodies, is also an option for some patients, particularly those with severe symptoms. This treatment can provide rapid relief of symptoms, but it is typically used in conjunction with other therapies.

Regarding the use of alternative treatments, such as medicinal mushrooms like Lingzhi (Reishi), there is limited scientific evidence to support their effectiveness in treating CIDP or other autoimmune conditions. While some patients may seek complementary therapies, it is crucial to approach these options with caution and discuss them with a healthcare provider to avoid potential interactions with prescribed medications.

Rehabilitation plays a vital role in the management of CIDP. Physical therapy can help improve strength, mobility, and function, while occupational therapy may assist with daily activities. The rehabilitation plan should be tailored to the individual's needs and may evolve as their condition changes.

In summary, CIDP is a complex condition that requires a comprehensive treatment approach. While some patients may achieve significant improvement, others may experience ongoing challenges. The treatment plan should be individualized, taking into account the patient's specific symptoms, response to therapy, and overall health. Regular follow-up with healthcare providers is essential to monitor progress and make necessary adjustments to the treatment strategy. It is also important for patients and their families to stay informed and engaged in the management of the condition, advocating for their needs and exploring all available options for care.

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