Lymph Node Swelling and Allergic Reactions: A Guide - Internal Medicine

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There are severe swellings in areas with lymph nodes, such as multiple enlarged nodes in the upper thighs and armpits, which are increasing in size and are painless.
What could be the cause? Additionally, I have reactions to various foods, such as a small amount of dairy products and lotus seeds.
On the same day after consuming them, my skin shows signs of inflammation and itching, and I tend to scratch.
I have a history of allergic constitution and have been visiting a dermatologist for many years.
Thank you.

i, 30~39 year old female. Ask Date: 2008/12/10

Dr. Lin Mingfeng reply Internal Medicine


Localized lymphadenopathy usually indicates an infection in the surrounding area.
If multiple sites are involved, it is more likely to be a systemic response.
Certain infections, such as toxoplasmosis or cat scratch fever, can cause lymphadenopathy in different locations.
Additionally, some diseases that affect the immune system, such as Kikuchi disease or HIV/AIDS, may also present with lymphadenopathy.
Another possibility is lymphoma.
Therefore, differential diagnosis should include a thorough medical history, physical examination, and laboratory tests, such as a complete blood count.
Some individuals may also experience heightened allergic reactions.
Blood tests can help identify specific allergens, allowing for the reduction of exposure to these triggers.
Furthermore, it is important to avoid scratching to prevent cellulitis.
If itching is severe, medications can be used for relief.

Reply Date: 2008/12/10

More Info


Lymph node swelling, particularly in areas such as the groin and armpits, can be concerning, especially when accompanied by allergic reactions to various foods. Understanding the relationship between lymph nodes and allergic responses is crucial for managing your health.

Lymph nodes are small, bean-shaped structures that are part of the lymphatic system, which plays a vital role in the immune response. They filter lymph fluid and house immune cells that help the body fight infections and diseases. Swelling of lymph nodes, known as lymphadenopathy, can occur for several reasons, including infections, autoimmune diseases, and malignancies. In your case, the swelling is not painful, which can sometimes indicate a less urgent issue, but it still warrants attention.

Given that you have a history of allergic reactions, it is possible that your lymph node swelling is related to an immune response triggered by allergens. Allergies occur when the immune system overreacts to substances that are typically harmless, such as certain foods. In your case, you mentioned reactions to dairy products and lotus seeds, which suggests that your immune system may be responding to these allergens by producing antibodies, leading to inflammation and swelling in the lymph nodes.

The fact that your lymph nodes are swelling and you are experiencing skin inflammation and itching indicates that your body is reacting to something, possibly an allergen. This could be a food allergy or another type of allergic reaction. It is essential to identify the specific triggers of your allergies to manage your symptoms effectively. Keeping a food diary may help you track which foods lead to reactions, allowing you to avoid them in the future.

In terms of management, it is advisable to consult with an allergist or immunologist who can perform specific tests, such as skin prick tests or blood tests, to identify your allergens. They may also recommend treatments such as antihistamines to alleviate your allergic symptoms and corticosteroids to reduce inflammation if necessary.

Additionally, the swelling of lymph nodes should be monitored. If the swelling persists, increases, or is accompanied by other symptoms such as fever, night sweats, or unexplained weight loss, it is crucial to seek medical attention promptly. These could be signs of a more serious condition that requires further investigation.

In summary, the swelling of your lymph nodes in conjunction with allergic reactions suggests an immune response to allergens. It is essential to consult with a healthcare professional to determine the underlying cause and appropriate treatment. Regular follow-ups and monitoring of your symptoms will help ensure that any potential issues are addressed promptly. Remember, managing allergies effectively can significantly improve your quality of life and reduce the risk of complications associated with lymphadenopathy.

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