Managing Hyperthyroidism: Should You Stop Inderal When Trying to Conceive? - Internal Medicine

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Hyperthyroidism is being treated with Inderal three times a day, and the heart rate is approximately 110-125 beats per minute.
If you are considering pregnancy, should you stop the medication? If you stop the medication and experience an increased heart rate, are there alternative medications available? Thank you.

io, 30~39 year old female. Ask Date: 2008/12/29

Dr. Lü Jing reply Internal Medicine


Hello: It is best to first control hyperthyroidism to normal levels, ideally with a lower dosage of medication.
Using Propylthiouracil is preferable.
If the heart rate is still too high, taking Inderal is possible for pregnancy, but it is advisable to discontinue the medication during delivery due to potential concerns.
It is not recommended for use in pregnant women unless absolutely necessary, and there are no reports of teratogenic effects.

Reply Date: 2008/12/29

More Info


When managing hyperthyroidism, particularly in the context of trying to conceive, it's essential to consider both the implications of the medication you're currently taking and the potential effects on your health and pregnancy. Inderal (propranolol) is a non-selective beta-blocker commonly used to manage symptoms of hyperthyroidism, such as rapid heart rate (tachycardia), anxiety, and tremors. It works by blocking the effects of adrenaline on the heart and blood vessels, which can help reduce heart rate and alleviate some of the symptoms associated with hyperthyroidism.

1. Should You Stop Inderal When Trying to Conceive?
The decision to stop Inderal when trying to conceive should be made in consultation with your healthcare provider. While Inderal is not contraindicated in pregnancy, it is essential to weigh the benefits against any potential risks. Propranolol has been used safely during pregnancy, but it can cross the placenta and may affect fetal heart rate and growth. Therefore, if you are planning to conceive, your doctor may recommend a careful evaluation of your current treatment plan.

2. What Happens If You Stop Inderal?
If you discontinue Inderal, you may experience a rebound effect, where your heart rate could increase significantly, potentially leading to symptoms such as palpitations, anxiety, and increased blood pressure. It is crucial to have a plan in place to manage these symptoms if you decide to stop taking the medication. Your healthcare provider may suggest a gradual tapering of the dose rather than an abrupt cessation to minimize withdrawal symptoms and monitor your heart rate closely.

3. Are There Alternative Medications?
If stopping Inderal is necessary, your doctor may consider alternative medications to manage your hyperthyroidism symptoms. Options may include other beta-blockers that are considered safer during pregnancy, such as metoprolol, or antithyroid medications like methimazole or propylthiouracil (PTU). However, these medications also have their own considerations in pregnancy, and your doctor will help you navigate these choices based on your specific health needs and the stage of your pregnancy.

4. Monitoring and Follow-Up:
Regardless of the medication plan, regular monitoring of your thyroid levels and heart rate is essential. Hyperthyroidism can lead to complications if left untreated, including increased heart rate and potential heart issues. Your healthcare provider may recommend regular follow-ups to adjust your treatment as needed, especially as you approach conception and during early pregnancy.

5. Lifestyle Considerations:
In addition to medication management, lifestyle changes can also play a significant role in managing hyperthyroidism symptoms. Stress reduction techniques, regular exercise, and a balanced diet can help improve overall well-being and may mitigate some symptoms associated with hyperthyroidism.

In conclusion, while Inderal can be effective in managing hyperthyroidism symptoms, the decision to continue or discontinue its use while trying to conceive should be made collaboratively with your healthcare provider. They will consider your specific health status, the severity of your hyperthyroidism, and any potential risks to both you and your future pregnancy. Always communicate openly with your healthcare team about your plans for conception and any concerns you may have regarding your treatment.

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