Impact of Anesthesia Dosage on Myasthenia Gravis Patients During Tooth Extraction - Internal Medicine

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I have myasthenia gravis and have been off medication for several years.
Recently, I experienced inflammation and swelling of my wisdom tooth.
I have taken antibiotics (B.B.
Clindamycin) for 6 days and pain relief and anti-inflammatory medication (Voren).
If I undergo a minor surgical procedure to extract the tooth, will the amount of anesthetic used have any impact? Thank you.

Miss Peng, 30~39 year old female. Ask Date: 2009/01/07

Dr. Chen Junwei reply Internal Medicine


Hello: Currently, your myasthenia gravis has been in remission for several years without any recurrence, so it is less likely to be triggered by minor stress or medications.
Additionally, tooth extraction anesthesia is local and should have minimal impact.
It is recommended that you return to the neurology outpatient clinic for a consultation with a specialist.
Thank you!

Reply Date: 2009/01/07

More Info


When it comes to the impact of anesthesia dosage on patients with Myasthenia Gravis (MG) during dental procedures such as tooth extraction, it is crucial to understand the unique challenges that this condition presents. Myasthenia Gravis is an autoimmune disorder characterized by weakness and rapid fatigue of voluntary muscles, which can be exacerbated by certain medications, including anesthetics.

In patients with MG, the use of anesthesia must be approached with caution. The primary concern is that many anesthetic agents can interfere with neuromuscular transmission, potentially worsening the muscle weakness associated with MG. For instance, neuromuscular blocking agents, which are sometimes used during surgical procedures, can lead to prolonged muscle weakness and respiratory complications in MG patients. Therefore, it is essential for your dental care provider to be aware of your condition and to tailor the anesthetic plan accordingly.

In your case, since you have been off medication for several years, it is important to communicate this to your dentist or oral surgeon. They may opt for a local anesthetic, which is typically safer for MG patients compared to general anesthesia. Local anesthetics, when administered in appropriate dosages, usually do not significantly affect neuromuscular transmission and can provide effective pain control during the extraction of your wisdom tooth.

The dosage of local anesthetic is also a critical factor. Using a lower dose may be beneficial in minimizing the risk of exacerbating your symptoms. It is advisable to discuss with your dentist the possibility of using a reduced dosage of anesthesia, especially since you have a history of MG. Additionally, your dentist may want to monitor you closely during and after the procedure to ensure that you do not experience any adverse effects.

Furthermore, the use of certain medications you mentioned, such as Clindamycin and Voren (an anti-inflammatory), should also be considered. Clindamycin is generally safe for MG patients, but it is always wise to confirm with your healthcare provider. Voren, being a non-steroidal anti-inflammatory drug (NSAID), can help manage pain and inflammation post-extraction, but it should be used judiciously, especially if you have any other underlying health conditions.

In summary, the impact of anesthesia dosage on Myasthenia Gravis patients during tooth extraction is significant and requires careful consideration. It is essential to communicate your medical history with your dentist, who can then devise a safe and effective anesthetic plan tailored to your needs. Always ensure that your dental team is aware of your condition and any medications you are currently taking, as this will help them provide the best care possible while minimizing risks associated with anesthesia. If you have any concerns or experience any unusual symptoms during or after the procedure, do not hesitate to reach out to your healthcare provider for guidance.

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