Is Sleepwalking Normal for Cancer Patients on Medication? - Pharmacology

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Is it normal for a cancer patient to experience sleepwalking after using a medication? The patient cannot be awakened even when called, and if they do wake up, they fall back asleep within seconds and continue sleepwalking.
The doctor has prescribed the medication to be taken every four hours, but the patient only takes it twice a day, one pill at a time.
Should the patient continue using this medication? I kindly ask for guidance from the physicians for the anxious family members.

Xiao Dao, 30~39 year old female. Ask Date: 2009/01/25

Dr. Hou Fangmin reply Pharmacology


Hello: I apologize for the delay in my response.
The medication you mentioned, which combines Acetaminophen and Tramadol, is used for pain relief in cancer patients when standard analgesics are ineffective.
Its side effects may include drowsiness and decreased attention, so caution is advised.

Important precautions: This medication can cause drowsiness and dizziness, so special care should be taken when driving or operating machinery.
Alcohol can enhance the side effects of this medication (such as dizziness, drowsiness, and impaired reaction time), so it should be avoided while taking it.
Dry mouth may occur, and patients can alleviate this by sucking on ice chips or candies.
Long-term use may lead to mild dependence.

What are the side effects and toxicity of prolonged Tramadol use? It is important not to suddenly discontinue the medication, as withdrawal symptoms may occur, including tremors, seizures, abdominal or muscle cramps, vomiting, and cold sweats.
Long-term use may also affect liver and kidney function.
Common side effects of Tramadol include urticaria, nausea, vomiting, constipation, drowsiness, dizziness, and headaches.
Additionally, abrupt cessation after long-term use may lead to withdrawal symptoms such as anxiety, insomnia, cold sweats, stiffness, tremors, vomiting, diarrhea, rebound pain, and hallucinations.

Regarding your mention of sleepwalking, this is relatively uncommon unless sleep medications are used, as some patients may experience sleepwalking as a side effect of those drugs.
The combination of Acetaminophen and Tramadol is considered a milder option for cancer patients, as stronger opioids like morphine have more side effects.
You may want to discuss this with the treating physician.
Wishing you peace and happiness.

Reply Date: 2009/01/25

More Info


Sleepwalking, or somnambulism, is a condition that can occur during sleep and is characterized by walking or performing other complex behaviors while in a state of sleep. While it is more commonly associated with children, it can also occur in adults, including those with underlying medical conditions or those taking certain medications. In the context of cancer patients, especially those on medications like acetaminophen and tramadol (the components of the medication you mentioned, 通安), sleepwalking can be a concerning side effect.

Tramadol, an opioid pain medication, is known to cause various side effects, including sedation, dizziness, and altered mental status. These effects can be exacerbated by the use of other sedatives or medications that affect the central nervous system. In cancer patients, who may already be experiencing fatigue, pain, and other symptoms, the addition of tramadol can lead to increased drowsiness and confusion. This may explain the sleepwalking behavior observed in your loved one.

The occurrence of sleepwalking in this scenario is not typical but can happen, especially if the patient is experiencing significant sedation from the medication. The fact that the patient is difficult to awaken during these episodes suggests a deeper level of sedation, which could be a result of the medication dosage or frequency of administration. The prescribing physician's recommendation of taking the medication every four hours may not be appropriate if the patient is only taking it twice a day, as this could lead to inadequate pain control and increased side effects.

It is crucial to address this issue with the patient's healthcare provider. Here are some considerations and recommendations:
1. Medication Review: The prescribing physician should review the patient's current medication regimen, including the dosage and frequency of tramadol. If the patient is experiencing significant side effects, it may be necessary to adjust the dosage or consider alternative pain management strategies.

2. Monitoring Side Effects: Keep a detailed log of the patient's sleepwalking episodes, including frequency, duration, and any other associated behaviors. This information can help the healthcare provider make informed decisions about the patient's treatment plan.

3. Alternative Pain Management: If tramadol is causing unacceptable side effects, the physician may consider alternative pain management options. This could include non-opioid analgesics, adjuvant medications (such as antidepressants or anticonvulsants), or even non-pharmacological approaches like physical therapy or acupuncture.

4. Sleep Hygiene: Encourage good sleep hygiene practices, such as maintaining a regular sleep schedule, creating a comfortable sleep environment, and avoiding stimulants close to bedtime. These practices can help improve overall sleep quality and may reduce the likelihood of sleepwalking.

5. Consult a Sleep Specialist: If sleepwalking persists, it may be beneficial to consult a sleep specialist. They can conduct a sleep study to evaluate the patient's sleep patterns and determine if there are underlying sleep disorders contributing to the behavior.

In conclusion, while sleepwalking is not a common side effect of tramadol, it can occur, particularly in patients who are already experiencing sedation or altered mental status. It is essential to communicate these concerns with the healthcare provider to ensure the patient's safety and well-being. Adjustments to the medication regimen may be necessary to mitigate these side effects while effectively managing pain.

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