Symptoms of Stomach Ulcers and Acid Reflux - Gastroenterology and Hepatology

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Symptoms of gastric ulcers and gastroesophageal reflux disease (GERD) include:


Hello Doctor: I have symptoms of gastric ulcer and gastroesophageal reflux disease.
After taking medication (Pantoprazole and Mosapride), I experience some abdominal bloating and pain before breakfast and after dinner.
I take Anperin 0.5mg to alleviate this discomfort, which provides some improvement, but I still occasionally experience abdominal bloating (before breakfast and after dinner).
Could the use of these gastrointestinal medications be causing these side effects? Are there any long-term side effects associated with taking Anperin? Is it safe to use Pantoprazole, a PPI, for an extended period, and could it lead to abnormal acid secretion after discontinuation? Does PPI completely suppress gastric acid secretion throughout the day, or does it only partially suppress it? Thank you~~~

kevin, 30~39 year old female. Ask Date: 2009/02/18

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello Mr.
Kevin: I am not familiar with the ingredients of Ampern, so I cannot provide any recommendations.
Long-term use of PPIs is generally considered safe, as gastric acid is still secreted in small amounts, and stopping the medication can return levels to normal (but may lead to reflux again!).
However, health insurance regulations require a four-month observation period before discontinuing the medication.
Changhua Hospital cares about your health.
Best regards, Chen Shidian.

Reply Date: 2009/02/18

More Info


Understanding the symptoms of stomach ulcers and acid reflux is crucial for effective management and treatment. Based on your description, it seems you are experiencing symptoms related to both conditions, which can often overlap. Stomach ulcers, also known as peptic ulcers, are sores that develop on the lining of the stomach or the upper part of the small intestine (duodenum). Symptoms typically include a burning sensation in the stomach, bloating, and discomfort, especially after meals. Acid reflux, or gastroesophageal reflux disease (GERD), occurs when stomach acid flows back into the esophagus, leading to symptoms like heartburn, regurgitation, and sometimes chest pain.

You mentioned that you are taking medications such as Pantoprazole (耐適恩), which is a proton pump inhibitor (PPI), and Mosapride (摩舒胃清), which is a prokinetic agent. PPIs are commonly prescribed to reduce stomach acid production, providing relief from symptoms associated with ulcers and GERD. While they are effective, long-term use of PPIs can lead to certain side effects, including an increased risk of gastrointestinal infections, nutrient malabsorption (such as magnesium and vitamin B12), and potential kidney issues.

Regarding your question about the side effects of these medications, it is indeed possible that the abdominal bloating and discomfort you experience, particularly before breakfast and after dinner, could be related to the medications. PPIs can alter the natural balance of stomach acid, which may affect digestion and lead to symptoms like bloating. Additionally, Mosapride, while intended to enhance gastric motility, can also cause gastrointestinal side effects in some individuals.

As for the long-term use of PPIs, they are generally considered safe for extended periods when used appropriately. However, it is essential to monitor for any adverse effects and to discuss with your healthcare provider whether you need to continue the medication or if a different approach might be more suitable. Stopping PPIs suddenly after long-term use can lead to rebound acid hypersecretion, where the stomach produces more acid than before, potentially worsening your symptoms.

PPIs do not completely suppress acid production throughout the day; rather, they significantly reduce it. The degree of acid suppression can vary based on the specific PPI and the dosage. While they are effective in managing symptoms, they do not cure the underlying conditions, so it is vital to address lifestyle factors such as diet, stress management, and avoiding triggers like smoking and alcohol.

In summary, while your current medications are helping manage your symptoms, it is essential to have an open dialogue with your healthcare provider about any ongoing discomfort and the potential side effects of long-term medication use. They may suggest adjustments to your treatment plan, including dietary changes or alternative medications, to help alleviate your symptoms more effectively. Regular follow-ups and monitoring are crucial to ensure that your treatment remains appropriate and effective for your condition.

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