Blood Clots: Causes, Treatments, and Medication Interactions

Thrombosis issues

Hello Doctor, I have been experiencing dizziness (not vertigo, but a sensation similar to an earthquake) for the past five years, which led me to seek follow-up care in the rheumatology and immunology department.
During this time, my antibody levels and inflammatory markers have remained stable and normal, with the exception of an elevated D-Dimer level of around 4 (normal is below 2).
Therefore, I have not met the criteria for Systemic Lupus Erythematosus (SLE).
I have been taking quinine and aspirin, and have switched to clopidogrel for several years.
Why has my thrombus data not decreased?
1.
What could be the underlying causes of my thrombosis? Are there specific reasons that could help tailor the treatment?
2.
Is it advisable to take aspirin or clopidogrel simultaneously with vitamin K supplements found in health foods?
Thank you very much.

MEGU, 40~49 year old female. Ask Date: 2009/02/20

Dr. Zeng Guosen reply Internal Medicine

Dear MEGU,
1.
A high D-dimer level does not necessarily indicate only thrombosis; moreover, aspirin is used to prevent the recurrence of thrombosis, not to address the underlying cause of your elevated D-dimer levels, so the data remains unchanged.
You should consult a hematologist to understand the reasons behind this.
2.
Aspirin can be taken concurrently with vitamin K.
However, I am not familiar with the specific components of the medication you mentioned, so I cannot provide an answer.
Wishing you safety and health,
Director Tseng Kuo-Sen
Department of Outpatient Services, Taoyuan General Hospital, Ministry of Health and Welfare

Reply Date: 2009/02/20

More Info

Understanding blood clots is crucial for managing health, especially for individuals with a history of symptoms like dizziness and abnormal D-Dimer levels. Blood clots can form due to various factors, including genetic predispositions, lifestyle choices, and underlying medical conditions.

Causes of Blood Clots
1. Genetic Factors: Some individuals have inherited conditions that increase their risk of clotting, such as Factor V Leiden mutation or Prothrombin gene mutation. These conditions can lead to hypercoagulability, making it easier for clots to form.

2. Medical Conditions: Conditions such as Aplastic Anemia, autoimmune diseases (like Lupus), and certain cancers can increase the risk of clot formation. In your case, the history of dizziness and elevated D-Dimer levels might indicate an underlying clotting disorder or vascular issue.

3. Lifestyle Factors: Sedentary behavior, obesity, smoking, and dehydration can contribute to the formation of blood clots. If you have a lifestyle that includes prolonged periods of inactivity, this could be a contributing factor.

4. Medications: Certain medications, including hormonal therapies and some cancer treatments, can increase the risk of clotting. It’s essential to review all medications you are taking with your healthcare provider.

Treatments for Blood Clots
1. Anticoagulants: Medications like aspirin and warfarin (or newer agents like direct oral anticoagulants) are commonly prescribed to prevent clot formation. You mentioned taking aspirin and a medication called 保栓通 (which I assume is a form of anticoagulant). These medications work by inhibiting the clotting process.

2. Lifestyle Modifications: Increasing physical activity, maintaining a healthy weight, and staying hydrated can help reduce the risk of clots.
3. Monitoring and Follow-Up: Regular follow-ups with your healthcare provider are essential to monitor D-Dimer levels and adjust treatment as necessary. If your D-Dimer levels remain elevated despite treatment, further investigation may be warranted to rule out other underlying conditions.

Medication Interactions
Regarding your question about the interaction between aspirin or 保栓通 and vitamin K supplements, it is important to note that vitamin K plays a crucial role in the clotting process. While aspirin works by inhibiting platelet aggregation, vitamin K is essential for synthesizing clotting factors in the liver.
- Aspirin: Generally, aspirin does not have a direct interaction with vitamin K, but it is always best to consult with your healthcare provider before adding any supplements to your regimen.

- Anticoagulants: If you are on warfarin or similar anticoagulants, vitamin K can counteract the effects of these medications, potentially leading to an increased risk of clotting. Therefore, it is crucial to maintain a consistent intake of vitamin K if you are on such medications.

Conclusion
In summary, the persistent elevation of D-Dimer levels and the history of dizziness warrant further investigation to identify the underlying cause of your blood clotting issues. It is essential to work closely with your healthcare provider to monitor your condition, adjust medications as necessary, and discuss any supplements you are considering. Lifestyle changes can also play a significant role in managing your risk of blood clots. Always prioritize open communication with your healthcare team to ensure the best outcomes for your health.

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