Can I Get Vaccinated for Hepatitis B Antibodies After Cure?

Q: Can I Get Vaccinated for Hepatitis B Antibodies After Cure?

In response to your questions： (1) Antiviral medications for hepatitis B carriers can effectively suppress the replication and activity of the hepatitis B virus in liver cells, reduce the level of liver inflammation, and prevent the deterioration of the condition in hepatitis B p

Can antibodies be administered after curing hepatitis B?

Hello Doctor: I am a carrier of Hepatitis B with a 33-year history.
I have currently cleared the e-antigen, but my antibodies are still negative.
Can I receive the antibody vaccine? My second question is: I want to become a father.
After my doctor determines that I can stop taking Baraclude, how long should I wait without medication before my partner can conceive to minimize any impact on the fetus? Thank you.

Mr. Su, 30~39 year old female. Ask Date: 2009/03/03

Dr. Zhang Siyuan reply Gastroenterology and Hepatology

In response to your questions: (1) Antiviral medications for hepatitis B carriers can effectively suppress the replication and activity of the hepatitis B virus in liver cells, reduce the level of liver inflammation, and prevent the deterioration of the condition in hepatitis B patients.
However, to date, no antiviral medications have been able to completely eliminate the hepatitis B virus from the human body, so even after successful treatment, individuals remain hepatitis B carriers.
Vaccination does not provide assistance in this regard.
(2) The drug Baraclude (entecavir) is not recommended for pregnant women due to reports of teratogenicity and carcinogenicity from animal studies.
As for whether it is harmful to future generations when taken by male humans, there is no experimental data to support this.

Reply Date: 2009/03/03

More Info

As a healthcare professional, it's important to address your concerns regarding Hepatitis B vaccination and the implications of being a carrier of the virus.
Firstly, regarding your question about vaccination for Hepatitis B antibodies after being a carrier: If you have been a Hepatitis B carrier for 33 years and have recently achieved seroconversion (meaning your e-antigen has turned negative), it is crucial to understand that this does not necessarily mean you have developed protective antibodies against Hepatitis B. The presence of antibodies (Anti-HBs) is what provides immunity against the virus. If your antibody levels are still negative, it indicates that you do not have sufficient protection against Hepatitis B, and vaccination may be advisable.
However, it’s essential to note that vaccination in individuals who are already infected or have been carriers may not be effective. The vaccine is designed to stimulate the immune system to produce antibodies, but if your immune system is already compromised due to chronic infection, the vaccine may not elicit the desired response. Therefore, it is best to consult with a healthcare provider who can evaluate your specific situation and determine whether vaccination is appropriate for you.

Regarding your second question about planning for parenthood: If you have been on antiviral medication (like entecavir, which is often referred to as "贝乐克" in Chinese) and your doctor has advised you to stop the medication, it is generally recommended to wait for a certain period before trying to conceive. The duration of this waiting period can vary depending on several factors, including the specific medication you were taking, your overall health, and the health of your partner.
Typically, it is advisable to wait at least 6 months after discontinuing antiviral therapy to ensure that the medication is fully cleared from your system and to monitor your Hepatitis B status. This waiting period allows for the assessment of any potential rebound in viral activity and ensures that your partner is not exposed to any residual effects of the medication.
Additionally, it is crucial to have regular follow-ups with your healthcare provider during this time to monitor your liver function and viral load. This will help ensure that you are in a stable condition before attempting to conceive.
In conclusion, while vaccination for Hepatitis B may be beneficial if you are not immune, it is essential to consult with a healthcare provider to assess your individual circumstances. Furthermore, when planning for a family, a waiting period after stopping antiviral medication is recommended to minimize any risks to your partner and future child. Always prioritize open communication with your healthcare team to make informed decisions regarding your health and family planning.

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