Post-Hysterectomy Hormone Therapy: Do You Need Estrogen? - Obstetrics and Gynecology

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After undergoing a hysterectomy and taking Darvon for six months, will I need to take estrogen, such as soy isoflavones, in the future? I have experienced weight gain while on the medication.
Will my weight gradually return to normal after stopping the medication? Additionally, what could be the cause of occasional dull pain in the ovarian area? Thank you.

Pipi, 40~49 year old female. Ask Date: 2009/03/19

Dr. Huang Jianxun reply Obstetrics and Gynecology


Dear Pipi: I do not have personal experience with Darunavir, so I am unclear about the medication's content.
Could you please provide the name of the Western medicine and its ingredients, or discuss it in detail with the prescribing physician? Wishing you peace and health.
Sincerely, Huang Jian-Hsun, Director of the Department of Obstetrics and Gynecology, Taoyuan General Hospital, Ministry of Health and Welfare.

Reply Date: 2009/03/19

More Info


Post-hysterectomy hormone therapy is a significant topic for many women who have undergone this procedure. After a hysterectomy, particularly if the ovaries are also removed (oophorectomy), the body experiences a significant drop in hormone levels, particularly estrogen. This can lead to various symptoms, including hot flashes, mood swings, and vaginal dryness, among others.
In your case, you mentioned that you have been taking Darvon (which I assume is a typo for a medication like Darvocet or a similar pain reliever) for six months. It’s important to clarify that pain medications do not replace hormone therapy. After a hysterectomy, especially if the ovaries are removed, estrogen replacement therapy (ERT) may be necessary to alleviate menopausal symptoms.
Regarding your question about whether you need to take estrogen, such as soy isoflavones, it largely depends on your symptoms and overall health. Soy isoflavones are plant-based compounds that can mimic estrogen in the body and may help alleviate some menopausal symptoms. However, they are not a direct substitute for estrogen therapy and may not be effective for everyone. If you are experiencing significant menopausal symptoms, consulting with your healthcare provider about the potential benefits of estrogen therapy would be advisable.

As for weight gain associated with medication, it is essential to consider that various factors can contribute to weight changes, including hormonal fluctuations, lifestyle changes, and dietary habits. If you have experienced weight gain while on medication, it may take some time for your body to adjust after discontinuing the medication. Generally, if the weight gain is due to medication, many women find that they gradually return to their pre-medication weight once they stop taking it, provided they maintain a healthy diet and exercise routine.

The "dull pain" you mentioned in the ovarian area could be due to several reasons. If your ovaries are still intact, they may still be functioning, and hormonal fluctuations can lead to discomfort. Other potential causes could include ovarian cysts, adhesions from the surgery, or even referred pain from other areas. It’s crucial to monitor this symptom and discuss it with your healthcare provider, especially if it persists or worsens.

In summary, after a hysterectomy, the need for estrogen therapy depends on individual symptoms and health status. If you are experiencing menopausal symptoms, discussing estrogen replacement options with your healthcare provider is essential. Weight changes may occur due to various factors, and any persistent pain should be evaluated by a medical professional to rule out any complications or underlying conditions. Always consult your doctor before making any changes to your medication or treatment plan.

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