Liver Explosion: Symptoms and Related Conditions - Gastroenterology and Hepatology

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Regarding liver issues?


Hello Dr.
Chen, could you please tell me what the symptoms of liver explosion are? Is liver explosion also referred to as acute liver failure?

Chen Tongxue, 20~29 year old female. Ask Date: 2009/03/28

Dr. Chen Qifeng reply Gastroenterology and Hepatology


Hello, acute liver failure (often referred to informally as "explosive liver failure," though this term is not used in medical terminology) refers to a rapid deterioration of liver function due to any cause, leading to hepatic encephalopathy within 8 weeks of onset.
Symptoms include severe jaundice and extremely elevated liver function tests (which can reach levels of 2000 or even 3000), with significant liver necrosis observed.
However, the most critical aspect is the presence of hepatic encephalopathy (elevated blood ammonia levels).
Once diagnosed with acute liver failure, the mortality rate exceeds 80%.
Best regards, Dr.
Chi-Feng Chen, Taoyuan Hospital, Department of Health.

Reply Date: 2009/03/28

More Info


Hello! The term "爆肝" (literally "exploding liver") is often used colloquially in Chinese to describe a condition of severe liver damage or dysfunction, typically associated with excessive alcohol consumption, viral hepatitis, or other liver diseases. In English, this might be referred to as "acute liver failure" or "acute liver injury," depending on the context.

Symptoms of Liver Explosion (Acute Liver Failure)
The symptoms of acute liver failure can vary widely but often include:
1. Jaundice: Yellowing of the skin and eyes due to the accumulation of bilirubin in the blood.

2. Abdominal Pain and Swelling: Discomfort or pain in the upper right quadrant of the abdomen, where the liver is located.

3. Nausea and Vomiting: These symptoms can be due to the liver's inability to process toxins.

4. Fatigue and Weakness: A general feeling of tiredness and lack of energy is common.

5. Confusion or Altered Mental State: This can occur due to the buildup of toxins in the bloodstream, affecting brain function (hepatic encephalopathy).

6. Bleeding or Bruising Easily: The liver produces proteins necessary for blood clotting; when it fails, bleeding can occur more easily.

7. Swelling in the Legs and Abdomen: This can be due to fluid retention (edema) or ascites, which is fluid accumulation in the abdominal cavity.


Related Conditions
Several conditions can lead to acute liver failure or severe liver dysfunction:
1. Viral Hepatitis: Hepatitis A, B, C, D, and E can cause liver inflammation and damage.

2. Alcoholic Liver Disease: Chronic alcohol consumption can lead to fatty liver, alcoholic hepatitis, and ultimately cirrhosis.

3. Drug-Induced Liver Injury: Certain medications, including acetaminophen (Tylenol) in excessive doses, can cause acute liver failure.

4. Autoimmune Hepatitis: The body's immune system attacks liver cells, leading to inflammation and damage.

5. Metabolic Disorders: Conditions like Wilson's disease (copper accumulation) or hemochromatosis (iron overload) can damage the liver.

6. Liver Tumors: Both benign and malignant tumors can affect liver function.


Importance of Medical Evaluation
If you or someone you know is experiencing symptoms suggestive of liver dysfunction, it is crucial to seek medical attention promptly. A healthcare provider can perform necessary tests, including blood tests (liver function tests), imaging studies (ultrasound, CT scan), and possibly a liver biopsy, to determine the underlying cause and appropriate treatment.


Conclusion
In summary, "爆肝" refers to severe liver dysfunction, often characterized by a range of symptoms including jaundice, abdominal pain, and altered mental status. It is essential to understand that this condition can arise from various underlying issues, and timely medical intervention is critical for managing the health of the liver. If you have concerns about liver health or symptoms, consulting a healthcare professional is the best course of action.

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Jaundice

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