Glaucoma: Key Questions and Treatment Insights - Ophthalmology

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Glaucoma issues?


First of all, thank you for the doctor's previous advice regarding the eye drops.
I now have some questions and would appreciate your guidance:
My husband, aged 44, had his intraocular pressure checked on February 2, 2009 (left eye 27 mmHg, right eye 28 mmHg).
An OCT (GLAUCOMA) examination indicated that the thickness of the optic nerve was somewhat reduced (average thickness: right eye 86.15, left eye 93.35; both eyes showed thinning in the inferior region according to the OCT report, falling within the "red" range).
The visual field test showed that the right eye's GHT was outside normal limits (MD: +0.28 dB, PSD: 2.71 dB, P <10%), but it would not currently affect daily vision.
The left eye's GHT was within normal limits (MD: +0.68 dB, PSD: 1.79 dB).
The doctor diagnosed him with early-stage chronic open-angle glaucoma.
He began using Timolol Chauvin 0.50% eye drops on February 21, 2009, and during a follow-up visit three weeks later (March 14, 2009), his intraocular pressure was measured at 19 mmHg in the left eye and 20 mmHg in the right eye.
The doctor did not increase or change the medication, advising him to continue using the same eye drops and return for a follow-up in two months.
1) Regarding the eye drops (Timolol Chauvin 0.50%), will their effects potentially further reduce intraocular pressure after two months, or is it more likely that the pressure will remain stable or slightly increase? Typically, do eye drops maintain their effectiveness for only six months before they stop further reducing intraocular pressure or start to show a slight increase?
2) Given that the optic nerve fibers are already thin and damaged, with current pressures at 19 mmHg in the left eye and 20 mmHg in the right eye, is this pressure level still considered suboptimal? Should the eye drops be changed to achieve a lower intraocular pressure to better protect the optic nerve? There is a suggestion that his intraocular pressure should ideally be controlled to 9 mmHg; is this correct? Please provide your valuable insights.
3) If the intraocular pressure drops too low, could a slight subsequent increase in pressure potentially harm the optic nerve due to the low baseline?
4) With current pressures at 19 mmHg in the left eye and 20 mmHg in the right eye, if this is still not ideal, would any further damage to the optic nerve occur more slowly and less severely compared to the previous pressures (27 mmHg in the left eye and 28 mmHg in the right eye)? Or is there no difference? Even if the intraocular pressure has improved, if there is still damage to the optic nerve, does the rate and severity of damage remain the same as before?
5) It is often said that glaucoma leads to a gradual narrowing of the visual field.
Now that my husband is using Timolol Chauvin 0.50% eye drops, if not properly controlled, will he experience a gradual narrowing of his peripheral vision, or will he suddenly notice a significant reduction in his visual field?
6) How much time should elapse before performing another OCT (GLAUCOMA) examination to more easily observe changes in the optic nerve?
7) If cataracts and glaucoma occur simultaneously, how should glaucoma be treated? After cataract surgery, can glaucoma eye drops be used to lower intraocular pressure?
I apologize for the numerous questions, and I sincerely appreciate your responses to these seven inquiries.
Thank you very much, and best wishes!

Tim Tim, 40~49 year old female. Ask Date: 2009/04/06

Dr. Xie Wenzhen reply Ophthalmology


Hello, sir: Thank you for your inquiry.
Here are my responses and suggestions:
1.
Each month, the response to medication can vary.
However, based on your husband's condition, continuing to use the eye drops to control intraocular pressure should help maintain or slightly reduce it further.

2.
Ideally, intraocular pressure should decrease by 10%-20%.
I recommend monitoring the situation with timolol eye drops for a while.
If the desired intraocular pressure is not achieved, consider adding another medication to lower the pressure.

3.
The optic nerve can tolerate some minor fluctuations in intraocular pressure, but if the pressure changes are too significant or unstable, it may be difficult for the optic nerve to withstand that.

4.
The extent of damage may be more gradual.

5.
Generally, the visual field narrows progressively.
However, if the changes in the visual field are only slight, most individuals may not notice them.
Therefore, by the time a patient perceives changes in their visual field, it has often already narrowed significantly.

6.
Six months .

7.
It is essential to first check whether the glaucoma is caused by cataract over-ripeness or swelling.
If so, performing cataract surgery may improve the glaucoma.
If not, then standard glaucoma treatment should be followed.
Additionally, this surgery can help lower intraocular pressure.

Finally, I wish you peace and happiness!

Reply Date: 2009/04/06

More Info


Thank you for your detailed questions regarding glaucoma and its management. I appreciate your proactive approach to understanding your condition and treatment options. Let’s address your inquiries one by one.

1. Effectiveness of Timolol Chauvin (0.50%): Timolol is a non-selective beta-blocker that reduces intraocular pressure (IOP) by decreasing aqueous humor production. After starting treatment, it typically takes a few weeks to see the full effect. While it is possible that the medication may continue to lower IOP slightly over the next two months, it is also common for the effect to stabilize. Generally, if the medication is effective, you might see a consistent IOP reduction, but it can also plateau or even slightly rebound if the body adjusts to the medication. Long-term use can sometimes lead to a reduced response, but this varies by individual.

2. Current IOP Levels and Treatment Adjustments: Your current IOP readings of 19 mmHg and 20 mmHg are indeed lower than your previous levels of 27 mmHg and 28 mmHg, which is a positive change. However, whether these levels are ideal depends on the overall health of your optic nerve and the degree of damage already sustained. The goal is to maintain IOP at a level that minimizes further damage to the optic nerve. While some guidelines suggest aiming for an IOP of 10-12 mmHg for those with significant optic nerve damage, the exact target can vary based on individual circumstances. It is essential to discuss with your ophthalmologist whether a further reduction in IOP is warranted.

3. Risks of Low IOP: If IOP is lowered too much, there is a theoretical risk that a slight rebound could cause stress on the optic nerve. However, this is generally not a significant concern unless the IOP drops to extremely low levels. Most patients tolerate a range of IOP without adverse effects, but it is crucial to monitor for any symptoms or changes in vision.

4. Comparative Damage Rates: If your IOP is controlled at lower levels, the rate of damage to the optic nerve should ideally be slower than at higher pressures. However, if there is already existing damage, the nerve may still be vulnerable. The relationship between IOP and optic nerve health is complex; while lower IOP generally correlates with less damage, it does not guarantee that further damage will not occur, especially if there are other risk factors at play.

5. Visual Field Changes: Glaucoma typically causes gradual peripheral vision loss, which may not be immediately noticeable until significant damage has occurred. Patients often do not realize their vision is narrowing until it becomes quite advanced. Regular visual field testing is essential to monitor changes over time.

6. Frequency of OCT Testing: The frequency of Optical Coherence Tomography (OCT) testing can vary based on your condition and the rate of change observed. Generally, it is advisable to have OCT performed every 6 to 12 months to track any changes in the optic nerve structure.

7. Managing Concurrent Cataracts and Glaucoma: When both cataracts and glaucoma are present, the treatment approach can vary. Typically, cataract surgery can be performed safely in patients with glaucoma, and it may even help lower IOP in some cases. After cataract surgery, it is usually safe to continue using glaucoma medications unless otherwise directed by your ophthalmologist.

In summary, managing glaucoma requires a tailored approach based on individual circumstances, including IOP levels, optic nerve health, and the presence of other conditions like cataracts. Regular follow-ups with your ophthalmologist are crucial to adjust treatment as needed and to monitor for any changes in your condition. Thank you for your thoughtful questions, and I wish you the best in managing your eye health.

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