Rare Skin Conditions: Purple Spots and Their Implications - Rare Disease

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Director Liu: Hello, I have irregular, non-itchy, non-painful purplish-red spots on my forearm, resembling livor mortis, which vary in severity.
They are less severe in the morning.
I also have similar spots on my body, but they are not as severe as those on my forearm.
I have consulted a Western medicine doctor who only prescribed some topical medications, which have not been effective.
I have heard that some cancers and syphilis can present with such symptoms.
Is that true? Could you please advise me on what my symptoms might indicate and which specialty I should consult?

Qiu Zhen Ren, 50~59 year old female. Ask Date: 2009/05/08

Dr. Liu Qingshan reply Rare Disease


Hello, you have developed erythema on your forearm that sometimes disappears.
This does not appear to be related to diseases caused by cancer or syphilis, and it may be associated with an allergic condition.
It is recommended that you visit a medical center to consult with a dermatologist or an immunologist/rheumatologist to understand the underlying issue.
This symptom is not likely to be classified as a rare disease, so you can feel reassured.

Reply Date: 2009/05/08

More Info


Understanding rare skin conditions, particularly the appearance of purple spots, can be quite complex and concerning. The symptoms you describe—irregular, non-itchy, and non-painful purple-red spots on your forearm—could potentially indicate a variety of conditions, some of which may be benign while others could be more serious.

Firstly, it’s essential to recognize that purple spots on the skin can arise from several causes. Commonly, they may be due to conditions such as petechiae or purpura, which are small blood vessels that have burst under the skin. These can be caused by a range of factors, including physical trauma, certain medications (like blood thinners), or underlying medical conditions that affect blood clotting or platelet function.

In your case, the fact that the spots are irregular and vary in severity could suggest a condition known as vasculitis, which involves inflammation of the blood vessels. However, it’s also important to consider other possibilities such as dermatological conditions like eczema or psoriasis, which can sometimes present with unusual pigmentation changes.

You mentioned that you have seen a Western doctor who prescribed some topical medications without noticeable improvement. This could indicate that the underlying cause of your symptoms may not be purely dermatological, and further investigation may be warranted. It’s crucial to consider systemic conditions that could manifest as skin changes. For instance, certain autoimmune diseases, infections, or even malignancies can present with skin symptoms, including purple spots.

Regarding your concern about cancer or syphilis, while it is true that some cancers (like leukemia) and infections (such as syphilis) can present with skin manifestations, it is essential to approach this with caution. Not all purple spots are indicative of such serious conditions. However, if you are experiencing other symptoms such as fatigue, unexplained weight loss, fever, or night sweats, it would be prudent to discuss these with your healthcare provider.

To address your symptoms effectively, I recommend the following steps:
1. Follow-Up Consultation: Schedule a follow-up appointment with a dermatologist or a hematologist. A dermatologist can provide a thorough examination of your skin and may perform a biopsy if necessary. A hematologist can evaluate your blood for any underlying conditions affecting clotting or platelet function.

2. Diagnostic Tests: Ask your doctor about blood tests that can assess your platelet count, clotting factors, and other relevant markers. Depending on the findings, further imaging studies or referrals to specialists may be necessary.

3. Document Changes: Keep a detailed record of any changes in your skin, including when the spots appear, their duration, and any associated symptoms. This information can be invaluable for your healthcare provider in making an accurate diagnosis.

4. Avoid Self-Diagnosis: While it’s natural to seek information about your symptoms, avoid jumping to conclusions about serious conditions without proper medical evaluation.
5. Stay Informed: Educate yourself about potential skin conditions, but rely on professional medical advice for diagnosis and treatment.

In conclusion, while purple spots on the skin can be alarming, they can arise from a variety of causes, many of which are treatable. It’s crucial to work closely with healthcare professionals to determine the underlying cause and appropriate treatment. Your health and peace of mind are paramount, and seeking further evaluation is the best course of action.

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