Gout: Causes, Symptoms, and Long-Term Management Options - Internal Medicine

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Dr. Tseng: Hello!


I experience gout attacks every year in June, July, and August (in my big toe).
Why does this happen? When it flares up, the pain is so intense that I can't sleep, and my toe becomes red and swollen! I have to rely on medication and injections to alleviate the pain.
I went to an immunology department at a hospital for blood tests, and the doctor mentioned it might be hereditary, but no one in my family has a history of gout.
Can you tell me if my symptoms can be treated, or will I have to rely on medication for the rest of my life?

Xiao Wei, 20~29 year old female. Ask Date: 2009/05/23

Dr. Zeng Guosen reply Internal Medicine


Hello, internet user: Gout is caused by elevated levels of uric acid in the blood.
It can be categorized into two main types: those with identifiable causes and those without.
If the cause of your high uric acid levels cannot be determined and you continue to experience frequent flare-ups, long-term use of urate-lowering medications is unavoidable.
This is because persistently high uric acid levels and frequent attacks can lead to chronic complications, including joint destruction, the formation of tophi, and even chronic gouty nephropathy.
The occurrences in June, July, and August may be due to the hot weather causing excessive sweating, leading to dehydration and increased uric acid concentration, which triggers acute attacks.
If the underlying cause can be identified or if efforts to maintain uric acid levels within the normal range are successful, there is a possibility of "curing" the condition.
However, given your situation, it may be challenging, and medication management may be necessary for some time before reassessing.

Reply Date: 2009/05/23

More Info


Gout is a form of inflammatory arthritis characterized by sudden and severe pain, redness, and swelling in the joints, most commonly affecting the big toe. It is caused by the accumulation of uric acid crystals in the joints, which can occur when there is an excess of uric acid in the blood, a condition known as hyperuricemia. Understanding the causes, symptoms, and long-term management options for gout is crucial for anyone experiencing this painful condition.


Causes of Gout
1. Uric Acid Levels: Gout occurs when uric acid levels in the blood become too high. Uric acid is a waste product formed from the breakdown of purines, substances found in certain foods and drinks, as well as in the body’s own cells. When the body produces too much uric acid or fails to eliminate enough of it through the kidneys, it can lead to the formation of crystals in the joints.

2. Diet: Certain foods can contribute to increased uric acid levels. Foods high in purines, such as red meat, organ meats, shellfish, and sugary beverages, can trigger gout attacks. Alcohol, especially beer, is also known to increase uric acid levels.

3. Genetics: While you mentioned that there is no family history of gout, genetics can still play a role. Some individuals may have a genetic predisposition to produce more uric acid or to have difficulty excreting it.

4. Other Health Conditions: Conditions such as obesity, hypertension, diabetes, and kidney disease can increase the risk of developing gout. Medications that affect uric acid levels, such as diuretics, can also contribute.


Symptoms of Gout
The symptoms of gout typically include:
- Intense Pain: Gout attacks often occur suddenly and can be extremely painful, often waking individuals from sleep. The pain is usually most severe within the first 12 to 24 hours.

- Swelling and Redness: The affected joint may become swollen, red, and warm to the touch.

- Limited Range of Motion: As the attack progresses, the ability to move the affected joint may be limited.


Long-Term Management Options
1. Medication: While medications can help manage acute attacks, they can also be used for long-term management. Nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, and corticosteroids are commonly used to relieve pain during an attack. For long-term management, urate-lowering therapy (ULT) such as allopurinol or febuxostat can help reduce uric acid levels and prevent future attacks.

2. Lifestyle Changes: Making dietary changes can significantly impact uric acid levels. Reducing the intake of purine-rich foods, avoiding alcohol, and staying hydrated can help manage gout. Maintaining a healthy weight through diet and exercise is also beneficial.

3. Regular Monitoring: Regular check-ups with your healthcare provider to monitor uric acid levels and kidney function are essential. This will help in adjusting medications and managing the condition effectively.

4. Education and Support: Understanding your condition and having a support system can help you manage gout better. Joining support groups or seeking counseling can provide emotional support and practical advice from others who experience similar challenges.


Conclusion
While gout can be a chronic condition requiring ongoing management, many individuals can achieve significant control over their symptoms through a combination of medication, lifestyle changes, and regular monitoring. It is essential to work closely with your healthcare provider to develop a personalized management plan that addresses your specific needs. Although you may feel that you are reliant on medication, with the right approach, it is possible to reduce the frequency and severity of gout attacks and improve your quality of life.

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