Gastrointestinal Issues: Ulcers, Reflux, and Medication Options - Gastroenterology and Hepatology

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I am a patient with a gastric ulcer and gastroesophageal reflux disease (GERD).
After taking medication for three months, I have recently been experiencing a taste of medication from my throat to my esophagus.
Could this be related to abnormal motility of the digestive organs and acid reflux? Is it appropriate to take Mosapride? Would it be more suitable to take medication that increases esophageal pressure to prevent acid reflux? Thank you for your response, doctor.

pl, 40~49 year old female. Ask Date: 2009/10/26

Dr. Lin Minghui reply Gastroenterology and Hepatology


Hello,
1.
It may be related to gastroesophageal reflux.

2.
Mosapride can promote gastrointestinal motility.

3.
Low pressure of the lower esophageal sphincter can sometimes lead to the reflux of stomach contents.
Certain external factors such as gastric distension, irritant foods, smoking, and medications can lower the pressure of the lower esophageal sphincter, making reflux more likely.
As for whether there are medications that can increase esophageal pressure to prevent acid reflux, further evaluation is needed.

Best regards,
Dr.
Lin Ming-Hui, Taoyuan Hospital, Department of Health.

Reply Date: 2009/10/26

More Info


Understanding gastrointestinal issues such as ulcers and gastroesophageal reflux disease (GERD) is crucial for effective management and treatment. As a patient with a history of gastric ulcers and GERD, it’s important to consider the underlying mechanisms of your symptoms and the medications you are taking.

Firstly, the sensation of a "medicinal taste" from your throat to your esophagus could indeed be related to abnormal gastrointestinal motility and acid reflux. When the stomach produces excess acid or when the lower esophageal sphincter (LES) does not function properly, gastric contents, including acid and partially digested food, can flow back into the esophagus. This condition is known as gastroesophageal reflux, which can lead to symptoms such as heartburn, regurgitation, and the sensation of a bitter or sour taste in the mouth or throat.

Regarding your question about Mosapride, it is a prokinetic agent that enhances gastrointestinal motility. It works by increasing the movement of the stomach and intestines, which can help in reducing symptoms associated with delayed gastric emptying and reflux. If your symptoms are related to poor motility, Mosapride may be beneficial. However, it is essential to consult your healthcare provider before starting any new medication, as they can assess your specific situation and determine if this medication is appropriate for you.

In terms of managing GERD, medications that increase the pressure of the lower esophageal sphincter can be helpful. These include certain types of prokinetic agents and medications that enhance the tone of the LES. Additionally, proton pump inhibitors (PPIs) or H2-receptor antagonists are commonly prescribed to reduce gastric acid production, thereby alleviating symptoms of reflux. However, long-term use of PPIs should be monitored due to potential side effects, including an increased risk of gastrointestinal infections and nutrient malabsorption.

Self-management strategies are also crucial in controlling GERD symptoms. Here are some recommendations:
1. Dietary Modifications: Avoid trigger foods that can exacerbate reflux symptoms, such as spicy foods, fatty foods, chocolate, caffeine, and acidic foods like citrus and tomatoes. Eating smaller, more frequent meals rather than large meals can also help.

2. Lifestyle Changes: Elevating the head of your bed, avoiding lying down immediately after meals, and maintaining a healthy weight can significantly reduce reflux symptoms. If you smoke, quitting can also improve your symptoms.

3. Stress Management: Since stress can exacerbate gastrointestinal symptoms, incorporating stress-reduction techniques such as mindfulness, yoga, or regular exercise may be beneficial.

4. Regular Follow-ups: Since you have been on medication for three months, it is essential to have regular follow-ups with your healthcare provider to monitor your symptoms and adjust your treatment plan as necessary.

In summary, your symptoms may indeed be related to gastrointestinal motility issues and acid reflux. Mosapride could be a potential option, but it’s essential to discuss this with your healthcare provider. Additionally, implementing lifestyle and dietary changes can significantly improve your quality of life and help manage your symptoms effectively. Always keep an open line of communication with your healthcare team to ensure the best possible outcomes for your gastrointestinal health.

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