HPV Type 40: Symptoms, Treatment, and Recovery Insights - Urology

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What are the effects of HPV type 40?


Last week, I had an HPV DNA test done at a urology clinic in the northern part of Taiwan.
I just browsed through the questions posted on the genital warts forum, and the doctors there all suggested that treatment should only be pursued if symptoms are present.
I did some research online and found that there are about one to two hundred types of HPV, which are classified into high-risk and low-risk groups based on their cancer-causing potential, rather than the common understanding of symptoms like warts.
From the discussions on the forum, it seems that the so-called "cauliflower" warts are mostly caused by low-risk types 6 and 11.

My questions are:
1) The HPV DNA report indicates that I am infected with HPV type 40, with a viral load of over 500 copies.
Does HPV type 40 have any noticeable clinical symptoms similar to the common understanding of genital warts?
2) Some medical websites state that most HPV infections will resolve on their own within a year due to the immune system.
However, it has been mentioned on the forum that genital warts do not resolve without treatment.
Is it true that, aside from types 6 and 11, other HPV types could also potentially resolve through the immune system, including HPV type 40?
3) The doctor I am currently seeing has suggested that I return to the clinic to receive antiviral medication, to take it for three weeks, and then stop, with a follow-up HPV DNA test four weeks later.
What is your recommendation on this? Thank you!

nick, 30~39 year old female. Ask Date: 2009/11/05

Dr. Xu Weikai reply Urology


NICK: Hello, HPV type 40? I'm not very familiar with this type.
My understanding is that the lower-numbered types (6, 11) are associated with warts and are less likely to cause cancer, while the higher-numbered types (16, 18) are more likely to be associated with cancers, such as cervical cancer.
I'm not sure about type 40, so I may need to consult an expert.
Generally, the body's immune system can fend off most of these viruses; out of the over 200 types of HPV, only about 15-20% require medical treatment.
Whether to use antiviral medication can depend on individual needs and the clinical experience of the physician.
If there are any unclear points, feel free to ask again, and we can further discuss and research together.
Concerned about your urology health, Taitung Hospital, Department of Health, Executive Yuan.
Director Hsu Wei-Kai.

Reply Date: 2009/11/05

More Info


Human Papillomavirus (HPV) is a group of more than 200 related viruses, some of which are classified as high-risk due to their association with cancer, while others are considered low-risk and are primarily linked to benign conditions such as warts. HPV type 40 is categorized as a low-risk type, similar to types 6 and 11, which are known for causing genital warts, commonly referred to as "cauliflower-like" growths.


1. Symptoms of HPV Type 40
HPV type 40 does not typically present with symptoms that are as pronounced as those caused by HPV types 6 and 11. While types 6 and 11 are well-known for causing visible genital warts, HPV type 40 may not lead to noticeable clinical manifestations. In many cases, individuals infected with HPV may remain asymptomatic, and the virus can be cleared by the immune system without any treatment. However, in some instances, HPV type 40 can lead to the development of benign lesions, but these are generally less common and less pronounced than those associated with the more notorious low-risk types.


2. Self-resolution of HPV Infections
It is well-documented that a significant percentage of HPV infections, including those caused by low-risk types, can resolve spontaneously. Research indicates that approximately 70-90% of HPV infections may clear within one to two years due to the body’s immune response. This self-resolution is not limited to types 6 and 11; other low-risk types, including HPV type 40, can also be cleared by the immune system. The immune system plays a crucial role in controlling and eliminating viral infections, and maintaining a healthy immune system through proper nutrition, exercise, and avoiding smoking can enhance this natural defense.


3. Treatment Recommendations
Regarding the treatment approach suggested by your physician, it is important to consider the context of your infection. While antiviral medications can be prescribed in certain cases, they are not universally required for all HPV infections, particularly for low-risk types like HPV 40. The recommendation to take antiviral medication for three weeks and then re-evaluate with another HPV DNA test after four weeks may be based on your specific clinical presentation and the physician's judgment.
If you are asymptomatic and there are no visible lesions, many healthcare providers may recommend a watchful waiting approach, monitoring for any changes rather than initiating aggressive treatment. If lesions develop or if there are other concerning symptoms, further intervention may be warranted.


Conclusion
In summary, HPV type 40 is a low-risk type that may not cause significant symptoms or lesions, and many infections can resolve on their own. It is essential to maintain regular follow-ups with your healthcare provider, especially if you notice any changes or new symptoms. Your physician's advice regarding antiviral medication should be weighed against your specific circumstances, and if you have concerns about side effects or the necessity of treatment, discussing these openly with your healthcare provider is crucial.
Lastly, continuing with the HPV vaccination is a proactive step in reducing the risk of HPV-related diseases, including those caused by high-risk types. It is always beneficial to stay informed and engaged in your health management, and seeking clarity from your healthcare provider is an excellent way to ensure you are making informed decisions about your health.

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