Revolutionary Treatment for Chronic Urticaria Using Autologous Blood - Dermatology

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I came across a headline today on Yahoo News that made me very happy, but I wanted to confirm it, so I would appreciate your thoughts on this report.
It states that the root cause of chronic urticaria could be treated using the patient's own blood! The Shuanghe Hospital has utilized autologous blood from chronic urticaria patients for "desensitization therapy," and the results show that 80% of patients experienced significant improvement.
One patient, Ms.
Yang, even resolved her long-standing insomnia, which previously occurred three times a week, now reduced to less than three times a season.
Dr.
Tseng Te-Peng, a dermatologist at Shuanghe Hospital, explained that urticaria can be classified into acute and chronic, with chronic urticaria lasting more than six weeks.
Only a small number of chronic urticaria patients can identify the allergic cause, and nearly 60% of the allergic triggers are found in their own blood.

In the study, nine patients tested positive for the "autologous serum injection test," confirming their allergic reactions to allergens in their own blood.
They underwent weekly venipuncture to draw about 3cc to 5cc of blood from their forearm, which was then directly injected into the gluteal muscle.
After eight weeks, this process could induce specific immune tolerance, thereby reducing reactions to allergens.
However, those who tested negative for the autologous serum injection showed poorer treatment outcomes.
Dr.
Tseng noted that after treatment, eight patients reported a significant reduction in medication frequency, with some no longer experiencing outbreaks at all.
This method effectively replaces the previous reliance on antihistamines or corticosteroids during flare-ups, leading to an improved quality of life for patients.

A Jie, 20~29 year old female. Ask Date: 2009/11/05

Dr. Jiang Zheen reply Dermatology


This is not considered a new therapy, but it does not mean that it is effective for everyone.

Reply Date: 2009/11/05

More Info


Chronic urticaria, or chronic hives, is a condition characterized by the recurrent appearance of itchy welts on the skin. It can be a frustrating and debilitating condition for many patients, as it often leads to significant discomfort and can interfere with daily activities. The treatment options for chronic urticaria have traditionally included antihistamines, corticosteroids, and other immunomodulatory therapies. However, recent advancements in treatment approaches, such as the use of autologous blood therapy, have shown promising results.

The report you mentioned from Shuang Ho Hospital highlights a novel approach where patients' own blood is used in a desensitization therapy for chronic urticaria. This method involves taking a small amount of the patient's blood, processing it, and then injecting it back into the patient. The idea behind this treatment is to induce a specific immune tolerance to the allergens present in the patient's blood, which may be contributing to their chronic urticaria.

According to the report, approximately 80% of patients experienced significant improvement after undergoing this treatment. This is a noteworthy statistic, as chronic urticaria can be notoriously difficult to manage, and many patients do not respond adequately to conventional therapies. The fact that some patients reported a reduction in the frequency of their hives and even improvements in associated issues like insomnia is particularly encouraging.

The mechanism by which autologous blood therapy works is still being studied, but it is believed that by exposing the immune system to the patient's own allergens, the body can learn to tolerate these substances rather than react to them. This approach is similar to other forms of immunotherapy used in allergy treatment, where gradual exposure to allergens can lead to desensitization.

However, it is important to note that this treatment may not be suitable for all patients. The report mentions that patients who tested positive for the autologous serum injection trial had better outcomes, while those who tested negative did not respond as well. This suggests that patient selection is crucial for the success of this therapy.

As with any medical treatment, there are potential risks and considerations. Patients should be thoroughly evaluated by a healthcare professional before undergoing this treatment to ensure it is appropriate for their specific condition. Additionally, the long-term effects and safety of this therapy need to be studied further to establish its efficacy and any potential side effects.

In conclusion, the use of autologous blood therapy for chronic urticaria represents an exciting development in the field of allergy treatment. While the initial results are promising, it is essential for patients to consult with their healthcare providers to discuss the best treatment options for their individual cases. As research continues, we may see more innovative approaches to managing chronic urticaria and improving the quality of life for those affected by this challenging condition.

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