the Risks: Medications and Benign Prostatic Hyperplasia - Urology

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Prostate health care


About a year ago, I had a persistent cough due to throat allergies, so I visited an ENT specialist and received medication.
Later, I checked the health department's website and found that one of the medications had a side effect of "benign prostatic hyperplasia" (I didn't note the name of the medication).
After taking it for about two days, I didn't want to continue.
Doctor, is this side effect temporary, or can it actually lead to prostate enlargement? Is this medication safe to take?

yi, 30~39 year old female. Ask Date: 2009/11/15

Dr. Lai Ronghao reply Urology


The side effects may refer to individuals with benign prostatic hyperplasia, which could lead to urinary difficulties, but it should not cause glandular hyperplasia.

Reply Date: 2009/11/15

More Info


When it comes to understanding the relationship between medications and Benign Prostatic Hyperplasia (BPH), it's important to recognize that certain medications can indeed have side effects that may exacerbate or contribute to the symptoms of BPH. BPH is a common condition in older men, characterized by an enlarged prostate gland that can lead to urinary difficulties such as increased frequency, urgency, and difficulty in urination.

Many medications can influence prostate health, and some antihistamines, decongestants, and certain antidepressants are known to potentially worsen BPH symptoms. For instance, medications with anticholinergic properties, which are often found in allergy medications, can lead to urinary retention by relaxing the bladder and increasing the resistance to urine flow. This can be particularly problematic for individuals who already have BPH, as it can exacerbate their symptoms.

In your case, since you mentioned experiencing throat allergies and subsequently taking medication prescribed by an ENT specialist, it’s crucial to identify the specific medication you were prescribed. While I cannot provide a definitive answer without knowing the exact drug, many over-the-counter antihistamines (like diphenhydramine) and some prescription medications can indeed have side effects that may lead to urinary retention or worsen BPH symptoms.

Regarding your concern about whether the side effects are temporary or if they can lead to permanent changes in prostate size, it’s generally understood that if a medication contributes to urinary retention or worsens BPH symptoms, those effects are often reversible upon discontinuation of the medication. However, if the medication is taken for an extended period, it may lead to more persistent symptoms or complications, especially in individuals who are already predisposed to BPH.

If you have taken the medication for only a couple of days and have already decided to stop due to concerns about its side effects, you are likely making a prudent choice. It’s always best to consult with your healthcare provider about any medications you are taking, especially if you have pre-existing conditions like BPH. They can provide guidance on alternative treatments that may not have the same side effects.

In summary, while some medications can exacerbate BPH symptoms, the effects are often temporary and reversible. It is essential to communicate openly with your healthcare provider about any concerns regarding medications and their potential side effects. They can help you weigh the benefits and risks of any treatment and suggest alternatives that are safer for your prostate health. If you experience persistent urinary symptoms or have concerns about BPH, further evaluation and management may be necessary.

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