HBsAg Levels and Their Implications for Liver Health

Q: HBsAg Levels and Their Implications for Liver Health

Hello, sir： A positive HBsAg indicates that you are a carrier of hepatitis B (have hepatitis B). <br>Please also test for HBeAg and follow up with a gastroenterologist to determine whether antiviral medication is needed. <br>Changhua Hospital cares about your health. <br>Chen Shi

HBsAg - Hepatitis B surface antigen

Hello, doctor.
May I ask if HBsAg (Hepatitis B surface antigen) can change? I previously had acute hepatitis, but my liver enzyme levels are now approaching normal (GOT: 40, GPT: 60).
However, the report shows that HBsAg is positive at 4318.
What does this mean? Will my risk of liver disease be higher in the future? Is there a way to take medication to lower this? Thank you.

WW, 20~29 year old female. Ask Date: 2009/11/19

Dr. Chen Shidian reply Gastroenterology and Hepatology

Hello, sir: A positive HBsAg indicates that you are a carrier of hepatitis B (have hepatitis B).
Please also test for HBeAg and follow up with a gastroenterologist to determine whether antiviral medication is needed.
Changhua Hospital cares about your health.
Chen Shidian.

Reply Date: 2009/11/19

More Info

The presence of HBsAg (Hepatitis B surface antigen) in your blood indicates an active Hepatitis B virus infection. The level of HBsAg, which you mentioned is (+) 4318, suggests a significant viral load. This means that the virus is actively replicating in your body, and you are considered infectious to others.
In your case, having previously experienced acute hepatitis but now having liver enzymes (GOT: 40, GPT: 60) trending towards normal is a positive sign. It indicates that your liver is recovering from the acute phase of the infection. However, the persistent positivity of HBsAg indicates that you are still a carrier of the virus, and it is crucial to monitor your liver health closely.

The implications of having a high HBsAg level are significant. It suggests that you are at an increased risk for developing chronic liver disease, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma (liver cancer) over time. The risk of these complications is particularly heightened if the HBsAg remains positive for more than six months, which would classify the infection as chronic.

Regarding your concern about medication, there are antiviral treatments available that can help manage chronic Hepatitis B infection. These medications can reduce the viral load, lower HBsAg levels, and improve liver function tests. Common antiviral medications include tenofovir and entecavir, which are effective in suppressing the virus and can lead to a decrease in HBsAg levels over time. However, the decision to start antiviral therapy should be made in consultation with a healthcare provider, who will consider factors such as your liver function, the presence of liver inflammation or damage, and your overall health status.

It is also essential to maintain regular follow-ups with your healthcare provider. This typically includes monitoring liver function tests, HBsAg levels, and possibly imaging studies like ultrasounds to assess liver health. Lifestyle modifications, such as avoiding alcohol, maintaining a healthy diet, and managing stress, can also support liver health.

In summary, your HBsAg level of (+) 4318 indicates an active Hepatitis B infection, and while your liver enzymes are improving, the presence of HBsAg suggests ongoing viral activity. Regular monitoring and potential antiviral therapy are crucial steps in managing your liver health and reducing the risk of future complications. Always consult with your healthcare provider for personalized advice and treatment options.

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