Should You Take Medication for Systemic Skin Conditions? - Dermatology

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Should systemic skin symptoms be treated with medication?


Hello Doctor: I have had skin issues since childhood, including palmar keratoderma (severe dryness, roughness, and scaling of the palms) and onychomycosis of the thumb.
I also suffer from severe eczema around the anal area (tinea cruris) and athlete's foot (tinea pedis), with significant skin breakdown, ulceration, redness, and onychomycosis.
These symptoms have troubled me for a long time, but every time I visit a dermatologist, I am prescribed topical ointments, which only provide temporary relief before the symptoms recur.
Could this be a systemic fungal infection? Would oral medication be necessary for effective treatment? Is there any blood test that I should undergo? Could these issues be indicative of underlying systemic conditions? If I take medication, is there a risk of liver or kidney damage?

Ms. Chen, 20~29 year old female. Ask Date: 2009/12/15

Dr. Huang Ruiyun reply Dermatology


Hello: I apologize, but your question cannot be accurately answered online, as I cannot see your symptoms.
Therefore, I am unable to provide a prescription or continue answering further questions.
Please consult a physician.
Wishing you all the best.

Reply Date: 2009/12/15

More Info


When dealing with systemic skin conditions, it is essential to understand the underlying causes and the appropriate treatment options available. Your symptoms, which include severe dryness and cracking of the palms (often referred to as "dishydrotic eczema" or "pompholyx"), onychomycosis (fungal infection of the nails), and eczema in the anal area, suggest a complex interplay of dermatological issues that may require a multifaceted approach.

Firstly, it is crucial to determine whether your skin conditions are indeed systemic or localized. Systemic skin conditions can be indicative of underlying health issues, such as autoimmune diseases, metabolic disorders, or chronic infections. In your case, the recurrence of symptoms despite topical treatments suggests that there may be an underlying factor that needs to be addressed.
You mentioned the possibility of a systemic fungal infection. While conditions like tinea (ringworm) can be localized, they can also become widespread if not treated effectively. Oral antifungal medications may be necessary for conditions like onychomycosis or extensive tinea infections, especially if topical treatments have failed. These medications can be more effective in clearing the infection from the root, particularly in cases where the fungus has penetrated the nail bed or skin layers.

Regarding blood tests, they can be beneficial in ruling out other conditions that may be contributing to your skin issues. Tests for fungal infections, autoimmune markers, or even allergy tests can provide valuable insights into your health. A dermatologist may recommend a skin scraping or culture to identify the specific type of fungus involved, which can guide treatment decisions.

As for concerns about the potential side effects of oral medications, such as liver or kidney damage, it is essential to have a discussion with your healthcare provider. Most oral antifungals are generally safe when used as directed, but they do require monitoring, especially in individuals with pre-existing liver or kidney conditions. Regular blood tests may be necessary to ensure that your liver and kidney function remain stable during treatment.

In addition to medication, lifestyle modifications can play a significant role in managing your skin conditions. Keeping the skin moisturized is crucial, especially for conditions like eczema and dry skin. Using emollient creams or ointments regularly can help maintain skin hydration and barrier function. Avoiding irritants, such as harsh soaps or detergents, and wearing breathable fabrics can also help reduce flare-ups.

Furthermore, dietary considerations may also impact skin health. A balanced diet rich in vitamins and minerals, particularly those that support skin health (like vitamins A, C, D, and E, as well as omega-3 fatty acids), can be beneficial. Staying hydrated and managing stress levels are also important, as stress can exacerbate skin conditions.

In summary, your situation may require a combination of oral medications, lifestyle changes, and possibly further diagnostic testing to identify the root cause of your skin issues. It is essential to work closely with a dermatologist who can tailor a treatment plan specific to your needs and monitor your progress. With the right approach, it is possible to achieve significant improvement in your skin conditions and overall quality of life.

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